Stereotactic Body Radiotherapy vs. Radiofrequency Ablation in the Treatment of Hepatocellular Carcinoma: A Meta-Analysis

Frontiers in Oncology
Yang-Xun PanYao-Jun Zhang

Abstract

Background: Both stereotactic body radiotherapy (SBRT) and radiofrequency ablation (RFA) are effective local treatments for hepatocellular carcinoma (HCC), but whether RFA is superior to SBRT is still controversial. Therefore, we performed a meta-analysis to compare the treatment outcomes of SBRT with RFA as curable or bridge intention. Methods: We searched online databases for studies that compared treatment outcomes for SBRT and RFA. Eligibility criteria included evaluation of local control, overall survival (OS), transplant rate, and post-transplant pathological necrosis. Results: As no randomized clinical trials met the criteria, 10 retrospective studies with a total of 2,732 patients were included. Two studies were in favor of SBRT in local control, two studies preferred RFA in OS, and others reported comparable outcomes for both. SBRT demonstrated significantly higher 1- and 3-year local control than RFA [odds ratio (OR) 0.42, 95% CI 0.24-0.74, P = 0.003; and OR 0.54, 95% CI 0.37-0.80, P = 0.002, respectively]. However, SBRT reported significantly shorter 1- and 2-year OS (OR 1.52, 95% CI 1.21-1.90, P = 0.0003; and OR 1.66, 95% CI 1.38-2.01, P < 0.00001, respectively). As bridge treatment, no significant difference was sh...Continue Reading

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Citations

Apr 11, 2021·Abdominal Radiology·Michael HellerDawn Owen
Apr 24, 2021·World Journal of Gastrointestinal Oncology·Ming-Cheng GuanTian Yang
Apr 16, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takahisa EriguchiNobuyuki Horita
Jun 25, 2021·Journal of Hepatocellular Carcinoma·Ashwathy S Mathew, Laura A Dawson

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