PMID: 8604963Mar 11, 1996Paper

Stereotactic brain biopsy in human immunodeficiency virus-infected patients

Archives of Internal Medicine
R LuzzatiE Concia

Abstract

To evaluate prospectively the diagnostic efficacy and safety of stereotactic brain biopsy and its impact on treatment, outcome, and survival in human immunodeficiency virus-infected patients with focal brain lesions. Computed tomography-guided stereotactic brain biopsy was performed in 26 patients, of whom 17 failed to respond to a 2- to 3-week anti- Toxoplasma regimen. Exclusion criteria for biopsy were overt acquired immunodeficiency syndrome for 2 years or longer, Karnofsky score less than 50, and severe coagulopathies. A definitive diagnosis was obtained in 24 patients (92%), of whom 12 (46%) had primary brain lymphoma, six (23%) had progressive multifocal leukoencephalopathy, and four (15%) had Toxoplasma encephalitis. Two thirds of contrast-enhancing lesions on computed tomography were lymphoma and three fourths of contrast-negative lesions were leukoencephalopathy. Three patients had biopsy-related cerebral hemorrhages (morbidity, 11.5%). Median follow-up and survival for the entire group were 24 weeks (range, 6 to 135 weeks). Twenty patients (77%) received specific therapy and 13 (50%) responded to treatment. Of 11 patients with lymphoma undergoing irradiation treatment (whole-brain radiotherapy in seven and gamma-knife...Continue Reading

Citations

Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel J Skiest
Sep 27, 2015·World Neurosurgery·J Quick-WellerG Marquardt
Jan 14, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Ashley M LeeLi Yang
Mar 31, 2009·Arquivos de neuro-psiquiatria·Manoel Jacobsen TeixeiraSérgio Rosemberg

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