Stereotactic fractionated radiotherapy of the resection cavity in patients with one to three brain metastases

Clinical Neurology and Neurosurgery
Angelika BilgerAnca-Ligia Grosu

Abstract

The goal of this study is to evaluate the role of stereotactic fractionated radiotherapy (SFRT) in patients with one to three brain metastases after surgical resection. We performed a retrospective single-institutional study in patients undergoing SFRT of surgical cavity after resection of ≤3 brain metastases. 60 patients with newly diagnosed brain metastases treated with SFRT following resection were included. The total irradiation dose was 30 Gy (5 Gy/d, BED 45 Gy) after complete macroscopical resection and 35 Gy (5 Gy/d, BED 52.5 Gy) in patients with macroscopic residual tumour after surgery. Macroscopic residual tumour was defined as contrast enhancement next to the resection cavity on the postoperative T1-MRI. The gross tumour volume (GTV) encompassing the residual tumour was delineated on the T1-MRI, the clinical target volume (CTV) encompassed the surgical cavity plus 1mm and the planning target volume (PTV) the CTV plus 2mm. Eight of 60 patients had no imaging follow-up due to morbidity/mortality. Two of 52 (3.8%) patients experienced local failures only, 25 of 52 (48.1%) patients experienced distant intracranial failures only and 4 (7.7%) patients experienced both local and distant intracranial failures. In summary, th...Continue Reading

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Citations

Oct 30, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lucyna KępkaBeata Czeremszyńska
Sep 10, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Christoph Straube, Stephanie E Combs
Sep 16, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ahmad Walid AyasMartin Kocher
Feb 3, 2018·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·E R VetlovaS M Banov
Mar 21, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Carsten NiederAnca L Grosu

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