Stereotactic radiation therapy for the treatment of functional pituitary adenomas associated with feline acromegaly

Journal of Veterinary Internal Medicine
Tiffany L WormhoudtSusan M LaRue

Abstract

Conventional fractionated radiotherapy has been shown to be partially effective for management of pituitary tumors in cats that cause acromegaly and diabetes mellitus (DM), but, the efficacy and safety of stereotactic radiation therapy (SRT) as a treatment for acromegalic cats has not been described. Stereotactic radiation therapy is an effective and safe treatment for controlling acromegaly associated with pituitary adenomas in cats. Additionally, SRT-treated acromegalic cats with DM will experience a decrease in insulin requirements after radiation therapy. Fifty-three client-owned cats referred to Colorado State University for SRT to treat pituitary tumors causing poorly controlled DM secondary to acromegaly. Retrospective study of cats treated for acromegaly with SRT between 2008 and 2016 at Colorado State University. Diagnosis of acromegaly was based on history, physical examination, laboratory results, and cross-sectional imaging of the pituitary. Signalment, radiation protocol, insulin requirements over time, adverse effects, and survival were recorded. Median survival time was 1072 days. Of the 41 cats for which insulin dosage information was available, 95% (39/41) experienced a decrease in required insulin dose, with 3...Continue Reading

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Citations

Dec 24, 2018·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Katherine S HansenMichael S Kent
Nov 3, 2020·Veterinary and Comparative Oncology·Katherine S HansenMichael S Kent
Feb 25, 2021·Journal of Veterinary Internal Medicine·Joe FennStijn J M Niessen
Feb 24, 2021·Journal of Veterinary Internal Medicine·Kirsten L van BokhorstBjörn P Meij
Jan 16, 2021·Journal of the American Animal Hospital Association·Rachel RivenburgAnnie V Chen
Mar 18, 2021·Annales d'endocrinologie·Fernanda Nastri GouvêaSofia Borin-Crivellenti
Apr 8, 2021·Journal of the American Veterinary Medical Association·Laura E O'SullivanAndrew Miller
Sep 4, 2021·Experimental and Therapeutic Medicine·Wei ZengHongfang Xu
Nov 14, 2021·American Journal of Veterinary Research·Maegan L Watson-SkaggsMichael W Nolan

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