PMID: 9525842Apr 3, 1998Paper

Stereotactic radiosurgery for brain metastases: comparison of lung carcinoma vs. non-lung tumors

Journal of Neuro-oncology
J WilliamsH Brem

Abstract

In the medical literature, stereotactic radiosurgery (SRS) for brain metastases results in rates of local control of 65 to 85 %. To define patient selection criteria, we measured the survival in a population with a high proportion of non-small cell lung carcinoma (NCS lung) metastases that occurred soon after primary diagnosis. Between 9/89 and 10/93 30 adults (21 M, 9 F) had SRS for metastatic NSC lung carcinoma (14 patients) vs. non-lung carcinomas (16 patients having breast (3), renal (3), melanoma (3), GI (2, thyroid (1) or carcinoma of unknown origin (4)). The metastases were solitary for 22 patients and multiple for 8 patients. Average ages (y) (+/-SD) were 58.6+/-10.4 for NSC lung patients and 53.4+/-12.5 (p = 0.32) for non-lung patients. The average interval (months) from diagnosis of the primary to metastasis was 23.8+/-41.4 for all patients. This interval was shorter for NSC lung patients: 3.1+/-6.0 vs. 48.0+/-51.7 (p < 0.001) for non-lung patients. Twenty seven patients had conventional radiotherapy (XRT) before (24 patients) or after (3 patients) SRS. Doses (cGy) were 3303+/-841 for 13 NSC lung patients and 4256+/-992 for 14 non-lung patients (p = 0.034). The median time from primary diagnosis to SRS was shorter for...Continue Reading

Citations

Mar 23, 2001·Breast Cancer Research and Treatment·G LedermanM Fine
Dec 31, 2003·Current Treatment Options in Oncology·Christoph PöttgenMartin Stuschke
Jan 1, 2010·Cancers·Alexander Chi, Ritsuko Komaki
Jan 14, 2009·Journal of Neuro-oncology·In-Young KimL Dade Lunsford
Dec 4, 2019·Indian Journal of Cancer·Vijith Shetty, Suresh Babu
Jun 18, 2014·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Dorota JezierskaWłodzimierz Liebert
Jul 1, 2004·Surgical Neurology·Jason SheehanL Dade Lunsford

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