Stereotactic radiosurgery for malignant melanoma to the brain

The Surgical Clinics of North America
S K SeungD A Larson

Abstract

This article offers support for using radiosurgery in the treatment of patients with melanoma brain metastases. Although patients with multiple metastases may fare somewhat worse than patients with single metastases, the difference is not statistically significant. The only significant prognostic factor that we were able to identify was smaller total target volume (favorable factor), although further study with longer follow-up and more patients may reveal other factors. Radiosurgery is appealing to patients and physicians because it is noninvasive and requires minimal hospitalization and recovery. Gamma Knife therapy offers patients a rapid method for achieving local control, which may be particularly important for patients who would otherwise be considered for specific protocols (such as some using IL-2) which preclude enrollment unless intracranial disease is controlled. We conclude that stereotactic radiosurgery is an effective treatment modality, with acceptable toxicity, for patients with either solitary or multiple melanoma metastases to the brain.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·B G FullerM A Bagshaw
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M P MehtaT J Kinsella
Jan 11, 1992·International Journal of Radiation Oncology, Biology, Physics·L E GasparJ G Cairncross
Mar 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G StevensA Coates
Jun 1, 1991·International Journal of Radiation Oncology, Biology, Physics·R J CoffeyL D Lunsford
Jan 1, 1992·CA: a Cancer Journal for Clinicians·C C BoringT Tong
Mar 1, 1992·Journal of Neurosurgery·J R AdlerD P Martin
Jan 1, 1991·Acta neurochirurgica. Supplementum·L KihlströmT Rähn
Jan 1, 1991·Acta neurochirurgica. Supplementum·R J CoffeyD J Bissonette
Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·D G Bragg, A G Osborn
Apr 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S LoefflerE Alexander
Feb 22, 1990·The New England Journal of Medicine·R A PatchellB Young
Oct 1, 1988·International Journal of Radiation Oncology, Biology, Physics·W R RateA T Turrisi
Mar 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M Diener-WestD F Nelson
Apr 1, 1986·Neurology·R A PatchellJ B Posner
Mar 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D E Weissman
Jun 1, 1985·Annals of Neurology·J G CairncrossR F DelMaestro
Jan 1, 1980·International Journal of Radiation Oncology, Biology, Physics·B BorgeltF R Hendrickson
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J M KurtzJ S Cooper
Sep 1, 1980·Neurology·F H Hochberg, A Pruitt
Jun 1, 1984·Cancer Treatment Reviews·N H Greig
Jan 1, 1983·Journal of Neuro-oncology·D RosnerW Lane
Jan 4, 1995·Journal of the National Cancer Institute·E AlexanderJ S Loeffler
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·E M NoordijkA R Wattendorff
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R CrossenE A Neuwelt
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerP K Sneed
Aug 1, 1993·Journal of Neurosurgery·R K BindalJ J Lee
Nov 1, 1993·Journal of Neurosurgery·S SomazaJ C Flickinger
Jul 1, 1954·Cancer·J H CHAOJ J NICKSON

❮ Previous
Next ❯

Citations

May 20, 1998·Seminars in Surgical Oncology·S M Sharpless, T K Das Gupta
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Cheng YuZbigniew Petrovich
Mar 23, 2001·Breast Cancer Research and Treatment·G LedermanM Fine
Mar 9, 2002·Journal of Neurosurgery·Vincenzo MingioneLadislau Steiner
Oct 31, 2002·Seminars in Oncology·James G Douglas, Kim Margolin
Oct 14, 2005·Expert Review of Anticancer Therapy·Robert R McWilliamsJan C Buckner
Dec 10, 2003·Mayo Clinic Proceedings·Robert R McWilliamsSvetomir N Markovic
May 13, 2008·Expert Review of Anticancer Therapy·Robert R McWilliamsPaul D Brown
Oct 11, 2017·Cancer Medicine·Wolfram E SamlowskiLawrence E Flaherty
Nov 5, 2020·Nature Reviews. Nephrology·Eric JonaschW Kimryn Rathmell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
J J GrobJ J Bonerandi
© 2022 Meta ULC. All rights reserved