Stereotactic radiosurgery for melanoma brain metastases in patients receiving ipilimumab: safety profile and efficacy of combined treatment

International Journal of Radiation Oncology, Biology, Physics
Ana P KiessKathryn Beal

Abstract

Ipilimumab (Ipi), a monoclonal antibody against cytotoxic T-lymphocyte antigen-4, has been shown to improve survival in patients with metastatic melanoma. In this single-institution study, we investigated the safety and efficacy of stereotactic radiosurgery (SRS) for patients with melanoma brain metastases (BMs) who also received Ipi. From 2005 to 2011, 46 patients with melanoma received Ipi and underwent single-fraction SRS for BMs. A total of 113 BMs (91% intact, 9% postoperative) were treated with a median dose of 21 Gy (range, 15-24 Gy). Ipi was given at 3 mg/kg (54%) or 10 mg/kg (46%) for a median of 4 doses (range, 1-21). Adverse events were recorded with the use of the Common Terminology Criteria for Adverse Events 3.0. Kaplan-Meier methods were used to estimate survival, and Cox regression was used to investigate associations. Fifteen patients received SRS during Ipi, 19 received SRS before Ipi, and 12 received SRS after Ipi. Overall survival (OS) was significantly associated with the timing of SRS/Ipi (P=.035) and melanoma-specific graded prognostic assessment (P=.013). Patients treated with SRS during or before Ipi had better OS and less regional recurrence than did those treated with SRS after Ipi (1-year OS 65% vs 5...Continue Reading

References

Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·E ShawL Martin
Apr 5, 2001·International Journal of Radiation Oncology, Biology, Physics·P E HuberJ Debus
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M FifeJ F Thompson
Aug 9, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T Gupta
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karsten A PilonesSandra Demaria
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M Zahidunnabi DewanSandra Demaria
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jedd D WolchokF Stephen Hodi
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Sep 10, 2010·Journal of the National Cancer Institute·Axel HoosJedd Wolchok
Oct 21, 2010·Cancer·Michael A DaviesAgop Bedikian
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Dec 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul W SperdutoMinesh Mehta
Mar 9, 2012·The New England Journal of Medicine·Michael A PostowJedd D Wolchok
Mar 30, 2012·The Lancet Oncology·Kim MargolinF Stephen Hodi
May 9, 2012·International Journal of Radiation Oncology, Biology, Physics·Emily F StamellIsaac Brownell
Jun 19, 2012·Journal of Neurosurgery·Jonathan P S KniselyVeronica L S Chiang
Nov 1, 2012·Frontiers in Oncology·Sandra Demaria, Silvia C Formenti
Feb 25, 2014·Cancer Immunology Research·Encouse B GoldenSilvia C Formenti

❮ Previous
Next ❯

Citations

Dec 30, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K A AhmedG T Gibney
Oct 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Megan E DalyKaren Kelly
Feb 3, 2016·Critical Reviews in Oncology/hematology·Magali FortUNKNOWN TRONE (Transatlantic Radiation Oncology NEtwork)
Nov 8, 2015·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Cédric Panje, Matthias Guckenberger
Mar 26, 2016·Frontiers in Oncology·Justine V Cohen, Harriet M Kluger
Nov 26, 2015·Advanced Drug Delivery Reviews·Daniel R Wahl, Theodore S Lawrence
Mar 10, 2016·Nature Reviews. Clinical Oncology·Michael B BernsteinJoe Y Chang
Apr 2, 2016·International Journal of Radiation Oncology, Biology, Physics·Colette J ShenLawrence R Kleinberg
Jul 19, 2015·Journal of Neuro-oncology·Daniel M TrifilettiJason P Sheehan
Aug 12, 2015·Future Oncology·Anna S Berghoff, Matthias Preusser
Jun 23, 2016·Gynecologic Oncology Reports·Maria B SchiavoneMario M Leitao
May 14, 2016·Expert Review of Neurotherapeutics·E Le RhunP Metellus
Feb 26, 2016·Cancer·April K S SalamaJoseph K Salama
Jun 28, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Andrea Riccardo FilippiPietro Quaglino
Jul 7, 2016·Japanese Journal of Clinical Oncology·Yusuke Sasaki, Ken Kato
Jul 13, 2016·Expert Review of Anticancer Therapy·Pol Specenier
Aug 9, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ilinca PoppDan G Duda
Sep 7, 2016·International Journal of Molecular Sciences·David A KircherSheri L Holmen
Oct 30, 2016·International Journal of Radiation Oncology, Biology, Physics·John P KirkpatrickHelen A Shih
Jan 20, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F Dhermain, E Deutsch
Dec 30, 2016·Radiation Oncology Journal·Taeryool Koo, In Ah Kim
Mar 10, 2017·Expert Review of Anticancer Therapy·Elisabetta TrinoAndrea Riccardo Filippi
Apr 5, 2017·Current Treatment Options in Neurology·Anna S Berghoff, Matthias Preusser
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liu YangSheng Hu
Jan 6, 2018·Biomedicines·Leila TchelebiHeath Mackley
Apr 1, 2018·Cancer·Daniel M Trifiletti, Paul D Brown
Sep 18, 2017·Clinical & Experimental Metastasis·Joo Yeon Nam, Barbara J O'Brien
Oct 19, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A V TalletY M Kirova
Feb 10, 2018·Immunotherapy·Maureen L AliruSunil Krishnan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Immunotherapy

Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest research on cancer immunotherapy here.