Stereotactic Radiosurgery for Pediatric Versus Adult Brain Arteriovenous Malformations

Stroke; a Journal of Cerebral Circulation
Ching-Jen ChenInternational Gamma Knife Research Foundation

Abstract

Background and Purpose- The aim of this international, multicenter, retrospective matched cohort study is to directly compare the outcomes after stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVM) in pediatric versus adult patients. Methods- We performed a retrospective review of patients with AVM who underwent SRS at 8 institutions participating in the International Gamma Knife Research Foundation from 1987 to 2014. Patients were categorized into pediatric (<18 years of age) and adult (≥18 years of age) cohorts and matched in a 1:1 ratio using propensity scores. Favorable outcome was defined as AVM obliteration, no post-SRS hemorrhage, and no permanently symptomatic radiation-induced changes. Results- From a total of 2191 patients who were eligible for inclusion in the overall study cohort, 315 were selected for each of the matched cohorts. There were no significant differences between matched pediatric versus adult cohorts with respect to the rates of favorable outcome (59% versus 58%; P=0.936), AVM obliteration (62% versus 63%; P=0.934), post-SRS hemorrhage (9% versus 7%; P=0.298), radiological radiation-induced changes (26% versus 26%; P=0.837), symptomatic radiation-induced changes (7% versus 9%; P=...Continue Reading

References

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Citations

Aug 8, 2019·Stroke; a Journal of Cerebral Circulation·Ching-Jen ChenUNKNOWN International Radiosurgery Research Foundation
Sep 10, 2020·Stereotactic and Functional Neurosurgery·Michaela DedeciusovaMarc Levivier
Mar 5, 2019·World Neurosurgery·Ching-Jen ChenUNKNOWN International Radiosurgery Research Foundation
Feb 8, 2020·Journal of Neurosurgery. Pediatrics·Ching-Jen ChenJason P Sheehan
May 16, 2020·Journal of Neurosurgery. Pediatrics·Michael M McDowellStephanie Greene

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