Stereotactic radiosurgery for trigeminal neuralgia utilizing the BrainLAB Novalis system

Technology in Cancer Research & Treatment
Hadi ZahraE Brian Butler

Abstract

Stereotactic radiosurgery (SRS) is one of the least invasive treatments for trigeminal neuralgia (TN). To date, most reports have been about Cobalt-based treatments (i.e., Gamma Knife) with limited data on image-guided stereotactic linear accelerator treatments. We describe our initial experience of using BrainLAB Novalis stereotactic system for the radiosurgical treatment of TN. A total of 20 patients were treated between July 2004 and February 2007. Each SRS procedure was performed using the BrainLAB Novalis System. Thin cuts MRI images of 1.5 mm thickness were acquired and fused with the simulation CT of each patient. Majority of the patients received a maximum dose of 90 Gy. The median brainstem dose to 1.0 cc and 0.1 cc was 2.3 Gy and 13.5 Gy, respectively. In addition, specially acquired three-dimensional fast imaging sequence employing steady-state acquisition (FIESTA) MRI was utilized to improve target delineation of the trigeminal proximal nerve root entry zone. Barrow Neurological Index (BNI) pain scale for TN was used for assessing treatment outcome. At a median follow-up time of 14.2 months, 19 patients (95%) reported at least some improvement in pain. Eight (40%) patients were completely pain-free and stopped all m...Continue Reading

References

Jan 7, 1967·British Medical Journal·W R Henderson
Oct 23, 1998·Stereotactic and Functional Neurosurgery·R F YoungA Posewitz
Dec 29, 1998·Archives of Neurology·D KondziolkaL D Lunsford
Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·C L RogersB L Speiser
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerL D Lunsford
Apr 5, 2003·Stereotactic and Functional Neurosurgery·Eugene HuangL Steven Carpenter
Sep 10, 2003·Journal of Neurosurgery·Zachary A SmithTimothy Solberg
Jan 8, 2005·Stereotactic and Functional Neurosurgery·Gregory J KubicekKathryn E Dusenbery
Mar 9, 2005·Journal of Applied Clinical Medical Physics·Bruce J GerbiWalter A Hall
Mar 31, 2005·Journal of Neurosurgery·Jason SheehanLadislau Steiner
May 28, 2005·Neurosurgery·Sean A McNattZbigniew Petrovich
Oct 6, 2005·Stereotactic and Functional Neurosurgery·Robert E DrzymalaDavid B Mansur
Dec 7, 2005·Neurosurgery·Gregory M RichardsMinesh P Mehta

❮ Previous
Next ❯

Citations

Apr 1, 2014·Otolaryngologic Clinics of North America·Jeffrey A Brown
Jan 11, 2012·Journal of Applied Clinical Medical Physics·Gocha KhelashviliJulius Turian
Apr 28, 2018·Journal of Neurosurgery·Constantin TuleascaMarc Levivier
May 12, 2016·Journal of Applied Clinical Medical Physics·Kang-Hyun AhnBulent Aydogan
Mar 4, 2020·World Neurosurgery: X·Carolina Venda NovaRicheal Ni Riordain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Stereotactic and Functional Neurosurgery
Gregory J KubicekKathryn E Dusenbery
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Mario Francesco FraioliDamiano Lisciani
Stereotactic and Functional Neurosurgery
J RégisJ-C Peragut
International Journal of Radiation Oncology, Biology, Physics
Alice V CheukWilliam F Regine
© 2022 Meta ULC. All rights reserved