Stereotactic Radiosurgery Results for Patients with 5-10 versus 11-20 Brain Metastases: A Retrospective Cohort Study Combining 2 Databases Totaling 2319 Patients.

World Neurosurgery
Masaaki YamamotoHidetoshi Kasuya

Abstract

The treatment of patients with ≥11 brain metastases (BMs) with stereotactic radiosurgery (SRS) alone has yet to be established. The aim of this study was to compare results of SRS alone in patients with 5-10 BMs versus 11-20 BMs. This was an institutional review board-approved, retrospective cohort study using our prospectively accumulated database including 1515 patients with 5-10 tumors and 804 patients with 11-20 tumors treated with Gamma Knife SRS by 2 experienced neurosurgeons between 1998 and 2018. The Kaplan-Meier method was applied to determine post-SRS survival times, and competing risk analyses were used to estimate cumulative incidences of the secondary end points. The post-SRS median survival time was slightly longer in the group with 5-10 tumors (7.7 months) than in the group with 11-20 tumors (6.5 months) (P < 0.0001). Median survival time differences were statistically significant for patients with lung cancers but not for patients with breast, gastrointestinal tract, kidney, and other cancers. Multivariable analysis revealed female sex, better Karnofsky performance scale score, controlled primary cancer, and absence of extracerebral metastases to be statistically significant predictors of longer survival in the ...Continue Reading

References

Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Masaaki YamamotoYoichi Urakawa
Jan 13, 2009·International Journal of Radiation Oncology, Biology, Physics·Yoshinori HiguchiNaokatsu Saeki
Jan 13, 2009·Journal of Korean Neurosurgical Society·Chang-Hyun KimJung-Il Lee
Jan 3, 2012·International Journal of Radiation Oncology, Biology, Physics·Masaaki YamamotoYoichi Urakawa
Oct 9, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hitoshi AiyamaBierta E Barfod

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