Stereotactic radiotherapy in metastatic breast cancer

The Breast : Official Journal of the European Society of Mastology
Marco Possanzini, Carlo Greco

Abstract

The treatment of metastatic breast cancer is largely focused on systemic therapy. However, over the past decades, there has been growing interest in the use of metastasis-directed therapy in selected cases presenting with an oligometastatic phenotype, i.e. low disease burden with a more indolent biology. Identification of the oligometastatic breast cancer population has, so far, proven elusive. Stereotactic radiotherapy offers an effective, non-invasive approach to ablate metastatic disease both in the brain and in extra-cranial settings. The advent of advanced imaging techniques for target definition, along with the ability to achieve highly conformal dose deposition with steep dose fall-off, enable safe implementation of extreme hypofractionated and single fraction regimens with ablative intent. There is growing evidence that radiation-based treatments are more cost-effective when compared to other ablative modalities. This article provides preliminary evidence that metastasis-direct ablation, with advanced radiotherapy techniques, may play an important role in the management of metastatic breast cancer patients, potentially improving clinical outcomes with minimal toxicity. However, prospective randomized controlled trials a...Continue Reading

Citations

Jul 18, 2020·Frontiers in Oncology·Fabian WeykampJuliane Hörner-Rieber
Nov 13, 2020·Technology in Cancer Research & Treatment·Jun WuFei-Fei Lin
Feb 8, 2021·Journal of Medical Imaging and Radiation Sciences·Anna GullhaugSafora Johansen
May 18, 2021·Indian Journal of Surgical Oncology·Parag IngleAjay Mehta
Jul 13, 2021·The Breast : Official Journal of the European Society of Mastology·Jean-Louis LacazeFlorence Dalenc

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