Stereotaxic rTMS for the treatment of auditory hallucinations in schizophrenia

Neuroreport
Carlos Schönfeldt-LecuonaUwe Herwig

Abstract

Auditory verbal hallucinations in schizophrenia may be due to dysfunctional inner speech-related cortical areas. Repetitive transcranial magnetic stimulation (rTMS) has been reported to be an effective treatment of hallucinations. In a cross-over sham controlled study, we guided rTMS stereotactically to inner speech-related cortical areas in hallucinating patients. These areas were identified individually prior to rTMS using fMRI in a subgroup of our patients. Active stimulation was applied over Broca's area and over the superior temporal gyrus as determined by fMRI, or according to structural images in the remaining patients. rTMS did not lead to a significant reduction of hallucination severity. Conclusively, rTMS has to be regarded critically as a possible novel tool for the treatment of hallucinations.

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Citations

Aug 23, 2005·Brain Topography·Carlos Schönfeldt-LecuonaUwe Herwig
Oct 12, 2005·Current Psychiatry Reports·Felipe Fregni, Alvaro Pascual-Leone
Mar 1, 2012·Schizophrenia Bulletin·Iris E C SommerMark van der Gaag
Mar 7, 2006·Clinical Neuropharmacology·Constantin TranulisDavid Gourion
Jan 12, 2010·Current Opinion in Psychiatry·Daniel M BlumbergerZafiris J Daskalakis
Jun 1, 2006·Neuropsychiatric Disease and Treatment·Gin S MalhiPerminder Sachdev
Dec 14, 2011·Neurophysiologie clinique = Clinical neurophysiology·J-P LefaucheurL Garcia-Larrea
Dec 10, 2013·Biological Psychiatry·Christina W SlotemaIris E C Sommer
Jun 7, 2007·The Spanish Journal of Psychology·Dolors Girbau
Dec 3, 2014·Psychiatry Research·Antoin D de WeijerEduard H J F Boezeman
Dec 3, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Derek K TracySukhwinder S Shergill
Mar 17, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Young-Chul ChungMyung-Hwan Ko
Mar 3, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Peter FalkaiUNKNOWN WFSBP Task Force on Treatment Guidelines for Schizophrenia
Aug 10, 2011·Brain Stimulation·Stéphane TringaliAnnie Moulin
Mar 17, 2010·Neurophysiologie clinique = Clinical neurophysiology·C Schönfeldt-LecuonaU Herwig
Oct 19, 2006·Neurophysiologie clinique = Clinical neurophysiology·G SabaM Leboyer
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Mar 8, 2013·Schizophrenia Research·K M J DiederenI E C Sommer
Sep 12, 2013·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·André Aleman
Jan 20, 2015·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Eun-Ji KimYoung-Chul Chung
Feb 5, 2008·The International Journal of Neuropsychopharmacology·Arielle D StanfordSarah H Lisanby
Aug 21, 2015·The Cochrane Database of Systematic Reviews·Nadine DougallAndrew McIntosh

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