Stereotypic Immune System Development in Newborn Children

Cell
Axel OlinPetter Brodin

Abstract

Epidemiological data suggest that early life exposures are key determinants of immune-mediated disease later in life. Young children are also particularly susceptible to infections, warranting more analyses of immune system development early in life. Such analyses mostly have been performed in mouse models or human cord blood samples, but these cannot account for the complex environmental exposures influencing human newborns after birth. Here, we performed longitudinal analyses in 100 newborn children, sampled up to 4 times during their first 3 months of life. From 100 μL of blood, we analyze the development of 58 immune cell populations by mass cytometry and 267 plasma proteins by immunoassays, uncovering drastic changes not predictable from cord blood measurements but following a stereotypic pattern. Preterm and term children differ at birth but converge onto a shared trajectory, seemingly driven by microbial interactions and hampered by early gut bacterial dysbiosis.

Associated Datasets

Citations

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Jan 4, 2019·Nature Reviews. Immunology·Petter Brodin
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Methods Mentioned

BETA
MDS
RNA-seq
cesarean section
PCA
PCR

Key Resources (RRID) Mentioned

2661851
2292654
1279194

Software Mentioned

PIANO
TDA
kohonen
bhSNE
MASS package
CyTOF
ProSeek
MATLAB
Ayasdi
stats

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