Stereotypy, locomotor and cataleptic effects produced by drugs influencing dopaminergic systems in a mutant strain of Wistar rats: a genuine model of basal ganglia dysfunction?

Behavioural Brain Research
L TurskiK H Sontag

Abstract

The mutant strain of Wistar rats carrying an autosomal recessive gene defect is characterized by a sequence of progressively developing behavioural alterations including hyperexcitability, tremor, olfactory and gustatory automatisms, bradykinesia, ataxia, rigidity, paresis and cachexia. The stereotypy and locomotor responses to increasing doses of apomorphine hydrochloride and D-amphetamine sulphate, and the catalepsy response to increasing doses of haloperidol were studied in mutant rats at the age of 6-7 weeks. In the mutants, both the stereotypy and locomotor responses to amphetamine were enhanced, while stereotypy and locomotor effects induced by apomorphine were unaltered. The cataleptic response to haloperidol was significantly diminished compared to controls. These findings indicate a derangement in the function of basal ganglia in the mutants.

References

Dec 15, 1978·Psychopharmacology·P Muller, P Seeman
Nov 7, 1975·Science·P M GrovesG V Rebec
Jun 22, 1972·The New England Journal of Medicine·H L KlawansA Barbeau
Jan 1, 1971·European Journal of Pharmacology·D IversenB Simpson
Dec 15, 1983·Experientia·W A TurskiL Turski
Jan 28, 1982·Brain Research·B ScattonG Bartholini
Feb 10, 1983·Nature·J W OlneyJ Labruyere
Mar 1, 1976·Neuroscience Letters·W PittermannF Deerberg
Oct 1, 1977·Neuroscience Letters·M F GiorguieffJ Glowinski
Nov 1, 1977·Neuroscience Letters·N N OsborneK H Sontag

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