Sterilizable gels from thermoresponsive block copolymer worms

Journal of the American Chemical Society
Adam BlanazsSteven P Armes

Abstract

Biocompatible hydrogels have many applications, ranging from contact lenses to tissue engineering scaffolds. In most cases, rigorous sterilization is essential. Herein we show that a biocompatible diblock copolymer forms wormlike micelles via polymerization-induced self-assembly in aqueous solution. At a copolymer concentration of 10.0 w/w %, interworm entanglements lead to the formation of a free-standing physical hydrogel at 21 °C. Gel dissolution occurs on cooling to 4 °C due to an unusual worm-to-sphere order-order transition, as confirmed by rheology, electron microscopy, variable temperature (1)H NMR spectroscopy, and scattering studies. Moreover, this thermo-reversible behavior allows the facile preparation of sterile gels, since ultrafiltration of the diblock copolymer nanoparticles in their low-viscosity spherical form at 4 °C efficiently removes micrometer-sized bacteria; regelation occurs at 21 °C as the copolymer chains regain their wormlike morphology. Biocompatibility tests indicate good cell viabilities for these worm gels, which suggest potential biomedical applications.

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Citations

Aug 7, 2013·ACS Applied Materials & Interfaces·Alideertu DongChokto Harnoode
Mar 29, 2016·Macromolecules·Sarah L CanningSteven P Armes
Jul 21, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Hanbin LiuYujun Feng
Jul 15, 2015·Biomacromolecules·Nicholas J WarrenSteven P Armes
Sep 13, 2016·Biomacromolecules·Héloïse Thérien-AubinEugenia Kumacheva
Feb 8, 2014·Journal of the American Chemical Society·Zhongfan JiaMichael J Monteiro
May 10, 2017·The Journal of Pharmacy and Pharmacology·Bahaa AzmyJonathan P Salvage
Mar 24, 2018·Macromolecular Rapid Communications·Jianbo TanLi Zhang
Feb 6, 2018·Macromolecular Rapid Communications·Meng HuoJinying Yuan
Mar 5, 2016·Chemical Communications : Chem Comm·Nghia P TruongThomas P Davis
Dec 24, 2014·Chemical Communications : Chem Comm·Jeong-Hee KimByeong-Hyeok Sohn
Jun 25, 2016·Chemical Society Reviews·J JenningsP B Zetterlund
May 19, 2018·Macromolecular Rapid Communications·Kevin M BurridgeDominik Konkolewicz
Jan 9, 2018·Polymer Chemistry·L P D RatcliffeS P Armes
Sep 13, 2017·Macromolecular Rapid Communications·Hongyao YinYujun Feng
Nov 26, 2015·Chemistry, an Asian Journal·Shi-Gui ChenZhan-Ting Li
Nov 22, 2013·Macromolecular Rapid Communications·Bunyamin KaragozThomas P Davis
Jun 21, 2018·Macromolecular Rapid Communications·Min ZengJinying Yuan
Aug 10, 2018·Macromolecular Rapid Communications·Song Yang KhorThomas P Davis
Nov 24, 2018·Angewandte Chemie·Gaëlle MellotJutta Rieger

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