Steroid-converting enzymes in human ovarian carcinomas.

Molecular and Cellular Endocrinology
Justin C ChuraPeter A Argenta

Abstract

Anti-estrogen therapies for treating ovarian carcinoma have had mixed outcomes suggesting some tumors may be estrogen-dependent. We assayed the activity levels of 17beta-hydroxysteroid dehydrogenase (17beta-HSD), 3beta-hydroxysteroid dehydrogenase (3beta-HSD), 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD/3-KSR) and estrone sulfatase in a series of ovarian epithelial carcinomas. 17beta-HSD activity ratios with estradiol (E(2)) and testosterone (T), and inhibition by isoform-specific inhibitors were used to estimate the contributions of 17beta-HSD isoforms. Activity levels were highest for estrone sulfatase, followed, respectively by 17beta-HSD, 3alpha-HSD/3-KSR, and 3beta-HSD. E(2)/T activity ratios varied widely between samples. A 17beta-HSD type 1 inhibition pattern was observed in 23% of the samples and a type 2 pattern in 25%. E(2) formation from estrone sulfate (E(1)S) was detected in 98% (47/48) of the samples. 17beta-HSD type 1, type 2 and type 5 mRNA was detected in matched primary tumor and metastases. Evaluation of 17beta-HSD and sulfatase activity levels, activity ratios and inhibition patterns may help predict tumor response to endocrine therapy.

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Citations

Mar 1, 2012·Journal of Physiology and Biochemistry·Mirja RotinenIgnacio Encío
Oct 10, 2012·Endocrine-related Cancer·Francesmary ModugnoSteffi Oesterreich
Sep 12, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Johanna SzabóErzsébet Mernyák
Apr 5, 2011·Steroids·René Maltais, Donald Poirier
Feb 9, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Daniela SchusterJerzy Adamski
Aug 3, 2010·Molecular and Cellular Endocrinology·Mitra NourbakhshFatemeh Karami-Tehrani
Jul 6, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Pierre R ProvostCharles H Blomquist
Oct 25, 2008·Gynecologic Oncology·Justin C ChuraPeter A Argenta
Jul 5, 2017·Frontiers in Pharmacology·Tea Lanišnik RižnerCsilla Özvegy-Laczka
May 21, 2015·Journal of Medicinal Chemistry·Mark P Thomas, Barry V L Potter

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