Steroid-exacerbated HIV-associated cutaneous Kaposi's sarcoma immune reconstitution inflammatory syndrome: 'Where a good intention turns bad'

International Journal of STD & AIDS
Shiven ChabriaOnyema Ogbuagu

Abstract

A 51-year-old man with head and neck skin lesions was diagnosed with Kaposi's sarcoma (KS) as his initial presentation of acquired immunodeficiency syndrome. Following initiation of antiretroviral therapy and subsequent full virologic suppression, his facial lesions worsened, consistent with immune reconstitution inflammatory syndrome (IRIS). He was started on glucocorticoids in an attempt to ameliorate the KS-IRIS but experienced paradoxical worsening of the KS lesions. Steroids were subsequently discontinued and he required chemotherapy for severe and cosmetically disfiguring skin lesions. This article describes the potential for worsening of KS lesions in individuals started on glucocorticoids for KS-IRIS as this has been reported rarely in published literature. The mechanisms underlying this phenomenon remain poorly understood but potential explanations are offered in the case discussion. This article aims to raise clinician awareness on the harms of steroid use in patients with KS-IRIS.

References

Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M BowerJ Stebbing
Oct 20, 2005·AIDS Patient Care and STDs·Rom S Leidner, David M Aboulafia
Apr 9, 2008·European Journal of Internal Medicine·Enrique Antón
Sep 24, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ryan J SullivanBruce J Dezube
Apr 3, 2014·European Journal of Dermatology : EJD·Georgios TyrosGeorgios Kontochristopoulos
Apr 11, 2014·Journal of the International Association of Providers of AIDS Care·A K ForrestelErin H Amerson
Oct 10, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Erin AmersonJeffrey Martin

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Citations

Jan 3, 2012·The Kaohsiung Journal of Medical Sciences·Chiung-Tang HuangTa-Chih Liu
Apr 17, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ching-Lan LuChien-Ching Hung
Nov 27, 2018·Expert Review of Clinical Pharmacology·Fiona V CresswellReinout Van Crevel

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Methods Mentioned

BETA
biopsy

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