Steroid hormone 20-hydroxyecdysone promotes CTL1-mediated cellular immunity in Helicoverpa armigera.

Insect Science
Gui-Jie WangJia-Lin Wang

Abstract

Mermithid nematodes, such as Ovomermis sinensis, are used as biological control agents against many insect pests, including cotton bollworm (Helicoverpa armigera). However, given the host's robust immune system, the infection rate of O. sinensis is low, thus restricting its widespread use. To understand the host defense mechanisms against mermithid nematodes, we identified and characterized a protein involved in the recognition of O. sinensis, the potential O. sinensis-binding protein C-type lectin 1 (HaCTL1a and/or HaCTL1b), which was eluted from the surface of O. sinensis after incubation with H. armigera plasma. HaCTL1b is homologous to the previously reported HaCTL1a protein. HaCTL1 was predominantly expressed in hemocytes and was induced by the steroid hormone 20-hydroxyecdysone through ecdysone receptor (HaEcR) or ultraspiracle (HaUSP), or both. Binding assays confirmed the interactions of the HaCTL1 proteins with O. sinensis but not with Romanomermis wuchangensis, a parasitic nematode of mosquito. Moreover, the HaCTL1 proteins were secreted into the hemocoel and promoted hemocyte-mediated encapsulation and phagocytosis. A knockdown of HaEcR and/or HaUSP resulted in compromised encapsulation and phagocytosis. Thus, HaCTL1...Continue Reading

References

Jan 1, 1995·Annual Review of Entomology·M R Strand, L L Pech
Jun 8, 1999·Annual Review of Immunology·A Aderem, D M Underhill
Aug 2, 2000·Trends in Endocrinology and Metabolism : TEM·T Kozlova, C S Thummel
Feb 24, 2001·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·I Y RauschenbachE Kuano
Jan 29, 2002·Nature Immunology·Jules A Hoffmann, Jean-Marc Reichhart
Feb 16, 2002·Developmental Biology·Richard Paul SorrentinoShubha Govind
Apr 16, 2002·Science·Ruslan Medzhitov, Charles A Janeway
Feb 20, 2003·Developmental and Comparative Immunology·Xiao-Qiang Yu, Michael R Kanost
Jun 18, 2004·Immunological Reviews·Håkan Steiner
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ayako WatanabeRyoichi Sato
Jun 15, 2007·Developmental and Comparative Immunology·Lian-Qin ChaiXiao-Fan Zhao
Feb 3, 2009·Developmental and Comparative Immunology·Yuan-Yuan TianJin-Xing Wang
Jun 4, 2010·The Journal of Biological Chemistry·Chong Han KimIn Hee Lee
Jul 16, 2011·EMBO Reports·Sang Woon ShinAlexander S Raikhel
Feb 11, 2014·Cell Communication and Signaling : CCS·Mei-Juan CaiXiao-Fan Zhao
Mar 13, 2014·Journal of Insect Physiology·Rahul Hepat, Yonggyun Kim
Mar 3, 2015·Scientific Reports·Di WangXiao-Fan Zhao
Nov 7, 2015·PLoS Pathogens·Paul R Johnston, Jens Rolff
Jan 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei SunZe Zhang
May 14, 2016·Nature Microbiology·Xiaojing PangGong Cheng
Aug 16, 2016·Developmental and Comparative Immunology·Ming-Yue ZhanXiang-Jun Rao
Aug 31, 2016·Nature Microbiology·Xiaojing PangGong Cheng
Mar 4, 2017·Developmental and Comparative Immunology·Pengfei HanJianzhen Zhang
Mar 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xueli WangZhen Zou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.