Steroid hormone effects on sonatomedin. I. Somatomedin action in vitro.

Endocrinology
L S PhillipsW H DAUGHADAY

Abstract

The effects of cortisol, estradiol, and testosterone on somatomedin action on cartilage incubated in vitro have been examined. The addition of hormones in the absence of serum had no effect on the incorporation of sulfate by cartilage from hypophysectomized rats, embryonic chicks, or normal young pigs. Normal human serum provided a source of somatomedin which stimulated the incorporation of sulfate by cartilage in a dose-response relationship; the potency of serum with and without added steroid hormone was determined after formal parallel-line analysis. Moderately supraphysiologic levels of cortisol, 17 beta-estradiol, and testosterone generally had little effect on somatomedin action in the test systems. Very high levels of serum cortisol (100-1000 mug/100 ml) inhibited somatomedin action on pig cartilage, but had little effect on rat or chick cartilage. A 20 ng/100 ml increase in serum estradiol had no effect on somatomedin action on chick cartilage, but appeared to enhance somatomedin action on pig cartilage. A 5 mug/100 ml increase in serum testosterone did not affect somatomedin action on either chick or pig cartilage. These studies suggest that the alteration of somatomedin action is not a major mechanism in the effect of...Continue Reading

Citations

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y IshidaJ N Heersche
Jan 1, 1981·Calcified Tissue International·I K Ashton, S Phizackerley
Jan 1, 1983·The International Journal of Biochemistry·A C HeringtonA D Kuffer
Jan 1, 1988·Psychoneuroendocrinology·A B Levy, W B Malarkey
Feb 21, 1980·The New England Journal of Medicine·L S Phillips, R Vassilopoulou-Sellin
Sep 1, 1977·The Journal of Clinical Investigation·R W FurlanettoA J D'Ercole
Mar 1, 1977·Clinics in Endocrinology and Metabolism·W H Daughaday
Jun 1, 1989·Metabolism: Clinical and Experimental·J F HofertL S Phillips
Mar 1, 1984·Clinics in Endocrinology and Metabolism·L S Phillips, T G Unterman
Jan 1, 1979·The British Journal of Nutrition·P G LunnS Austin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.