Steroid Hormone Receptor Signals as Prognosticators for Urothelial Tumor

Disease Markers
Hiroki Ide, Hiroshi Miyamoto

Abstract

There is a substantial amount of preclinical or clinical evidence suggesting that steroid hormone receptor-mediated signals play a critical role in urothelial tumorigenesis and tumor progression. These receptors include androgen receptor, estrogen receptors, glucocorticoid receptor, progesterone receptor, vitamin D receptor, retinoid receptors, peroxisome proliferator-activated receptors, and others including orphan receptors. In particular, studies using urothelial cancer tissue specimens have demonstrated that elevated or reduced expression of these receptors as well as alterations of their upstream or downstream pathways correlates with patient outcomes. This review summarizes and discusses available data suggesting that steroid hormone receptors and related signals serve as biomarkers for urothelial carcinoma and are able to predict tumor recurrence or progression.

References

Apr 1, 1997·Scandinavian Journal of Urology and Nephrology·G G Hermann, C B Andersen
Mar 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·X Garcia del MuroJ R Germà
Aug 3, 2001·Urological Research·S SaikawaK Okada
Dec 7, 2002·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·S CelayirS Dervisoglu
Feb 28, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Cynthia CohenTravis Larsen
Jun 1, 2005·European Urology·Bas W G van RhijnTheo H van der Kwast
Mar 17, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Esra UzaslanJosune Guzman
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Changping ZouH Barton Grossman
Apr 5, 2007·Journal of the National Cancer Institute·Hiroshi MiyamotoChawnshang Chang
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maha H A HussainUNKNOWN National Cancer Institute
Mar 4, 2008·Endocrine-related Cancer·Jian TengDale E Bjorling
Jun 6, 2008·Urology·Aimee M JohnsonJay E Reeder
Sep 16, 2008·Cancer Letters·Shuo WeiChing-Shih Chen
Oct 11, 2008·Endocrine-related Cancer·Stephen A BoorjianDonald J Tindall
Jan 27, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G K PhilipsUNKNOWN Cancer and Leukemia Group B
Jul 15, 2009·European Urology·Christian BolenzShahrokh F Shariat
Sep 24, 2009·British Journal of Cancer·K DietrichM R Karagas
Jul 2, 2010·Current Opinion in Urology·Emil ScosyrevEdward Messing
Aug 24, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Stylianos KontosGeorgia Sotiropoulou-Bonikou
Sep 3, 2010·Journal of Experimental & Clinical Cancer Research : CR·Qinchao YuZemi Zhang
Sep 4, 2010·Maturitas·Beverly J WolpertChristopher A Loffredo

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Citations

Jan 10, 2017·Expert Opinion on Therapeutic Targets·Taichi MizushimaHiroshi Miyamoto

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Methods Mentioned

BETA
PCR
transgenic
immunoprecipitation

Software Mentioned

UroVysion

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