Steroid hormone related effects of marine persistent organic pollutants in human H295R adrenocortical carcinoma cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Myrthe W van den DungenAlberTinka J Murk

Abstract

Persistent organic pollutants (POPs) such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorobiphenyl (PCB) 126 and 153, perfluorooctanesulfonic acid (PFOS), hexabromocyclododecane (HBCD), 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), tributyltin (TBT), and methylmercury (MeHg) can be accumulated in seafood and then form a main source for human exposure. Some POPs have been associated with changes in steroid hormone levels in both humans and animals. This study describes the in vitro effects of these POPs and mixtures thereof in H295R adrenocortical carcinoma cells. Relative responses for 13 steroid hormones and 7 genes involved in the steroidogenic pathway, and CYP1A1, were analyzed. PFOS induced the most pronounced effects on steroid hormone levels by significantly affecting 9 out of 13 hormone levels measured, with the largest increases found for 17β-estradiol, corticosterone, and cortisol. Furthermore, TCDD, both PCBs, and TBT significantly altered steroidogenesis. Increased steroid hormone levels were accompanied by related increased gene expression levels. The differently expressed genes were MC2R, CYP11B1, CYP11B2, and CYP19A1 and changes in gene expression levels were more sensitive than changes in hormone levels. ...Continue Reading

References

Jun 1, 1991·The Biochemical Journal·J P Landers, N J Bunce
Feb 1, 1994·American Journal of Epidemiology·G M EgelandW E Halperin
Oct 1, 1996·Archives of Environmental Contamination and Toxicology·J A StäbW P Cofino
Jul 27, 2000·Food Additives and Contaminants·A K LiemC Rappe
Apr 11, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J T SandersonM van den Berg
Jun 10, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Klara HilscherovaJohn P Giesy
Feb 11, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lih-Ann Li, Pei-Wen Wang
Jul 26, 2005·Steroids·Takeshi YamazakiShiro Kominami
Oct 13, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Merijn SchriksAlbertinka J Murk
Jun 30, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·J Thomas Sanderson
Aug 29, 2006·Ecotoxicology and Environmental Safety·Tannia GraciaJohn P Giesy
Sep 20, 2006·Journal of Toxicology and Environmental Health. Part a·Qing Qing LiJeffrey Philip Obbard
May 22, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lih-Ann Li
Aug 28, 2007·Chemosphere·Maaike BilauUNKNOWN Flemish Center of Expertise for Environment and Health
Feb 6, 2008·Toxicology Letters·Yuhe HePaul K S Lam
Apr 12, 2008·International Journal of Toxicology·Suel-Kee KimYong-Dal Yoon
Jun 21, 2008·International Journal of Hygiene and Environmental Health·Hermann FrommeDorothee Twardella
Dec 17, 2008·Environmental Health Perspectives·Mary E TurykHenry A Anderson
Apr 30, 2010·Environmental Science & Technology·C J A F KwadijkA A Koelmans
Mar 25, 2011·The Journal of Endocrinology·Yewei XingWilliam E Rainey
Jul 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M MontañoS Verhaegen
Jun 2, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M H BloklandM W F Nielen
Nov 6, 2012·Biological & Pharmaceutical Bulletin·Yaichiro Kotake
Dec 19, 2012·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Zuzana KnazickaPeter Massanyi

❮ Previous
Next ❯

Citations

Jan 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Alex OdermattRoger T Engeli
Jun 3, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R SalgadoA Lafuente
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Rohit BhandariJ Zach Hilt
May 6, 2020·Environmental Science and Pollution Research International·Li Li ShiHao Feng
Jan 27, 2019·Scientific Reports·Almudena Espín-PérezTheo M C M de Kok
Mar 19, 2021·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.