PMID: 11323396Apr 27, 2001Paper

Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas

Carcinogenesis
C E HudsonJ S Norris

Abstract

Syrian hamsters treated with estrogen and androgen for 8 months develop leiomyosarcomas in the vas deferens. Metabolism of estrogen by cytochrome P450s (CYPs) produces catechols and reactive oxygen species, and may contribute to tumor formation. To examine this issue, male hamsters were treated with 17 beta-estradiol (E2), testosterone propionate (TP) or both hormones. Reproductive tract tissues from control and treated animals were immunostained with antibodies specific for four CYP enzymes (1A1, 1A2, 1B1 and 3A1/2). Immunoreactive CYP1A1 was not found in the reproductive tract of control or treated animals. In untreated hamsters, CYP1A2 was detected only in principal cells of the caput epididymis. TP alone had no effect, but treatment with E2 induced expression of CYP1A2 in columnar epithelial cells throughout the epididymis and lining of the vas deferens. Treatment with E2 + TP blocked the induction of CYP1A2 seen in surface epithelial cells treated with E2 alone, but not the constitutive expression of this enzyme. Instead, simultaneous exposure to both hormones induced CYP1A2 in basal cells of the epididymis and vas deferens. CYP3A1/2 was not detected in the reproductive tract of control or TP-treated males, but immunostain...Continue Reading

Citations

Aug 9, 2002·European Journal of Pharmacology·Han-Jing XieMoustapha Hassan
Oct 22, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sabrina PetersonJohanna W Lampe
Sep 30, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Jakob O StrömAnnette Theodorsson
Aug 23, 2005·Cancer Letters·Yuki TsuchiyaTsuyoshi Yokoi
Feb 6, 2017·Clinical Science·Lea Gaignebet, Georgios Kararigas
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takashi TokizaneRajvir Dahiya

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