PMID: 1204635Dec 1, 1975Paper

Steroid-induced early protein synthesis in rat uterus and prostate

European Journal of Biochemistry
P PennequinE E Baulieu

Abstract

An early 'induced protein', after exposure of the rat uterus to estradiol, is detected among the soluble proteins with a double-labelling technique and electrophoretic fractionation. Efforts have been directed to establish the subcellular distribution of the induced protein, since such a protein, observable 1 h after hormone administration, may play an important role in the subsequent amplified responses, especially in terms of RNA synthesis. Moreover such an early discrete induced protein was sought in a comparable system responding to another hormone, namely prostate and seminal vesicles under androgens. The induced protein was not found in uterine nuclei of 21-day-old rats after 1 h of estradiol action in vivo and 1 h of tissue incubation with labelled leucine. This negative result summarizes a search among different nuclear protein fractions using various procedures; nor was induced protein observed in mitochondrial and microsomal pellets. Contrary to these negative findings, slight changes of histone labelling were observed under the experimental conditions used to demonstrate induced protein. In addition histone acetylation was increased after 1 h of estradiol action in vivo and 15 min tissue labelling in vitro with radio...Continue Reading

References

Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·A B DeAngelo, G I Fujimoto
Jan 1, 1972·Acta Endocrinologica. Supplementum·E E BaulieuC Raynaud-Jammet
Sep 21, 1973·Biochimica Et Biophysica Acta·S Chaudhuri
Sep 14, 1972·Biochimica Et Biophysica Acta·A Isotalo, R S Santti
Nov 1, 1972·Endocrinology·P M Spooner, J Gorski
Oct 14, 1971·Biochimica Et Biophysica Acta·C Raynaud-JammetE E Baulieu
Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·S LiaoA H Lin
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A Notides, J Gorski
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A B DeAngelo, J Gorski
Nov 20, 1968·Biochimica Et Biophysica Acta·C Vesco, S Penman
Jul 14, 1968·Journal of Molecular Biology·J Paul, R S Gilmour
Oct 1, 1965·Journal of Cellular Physiology·J GorskiJ A Nicolette
Sep 22, 1966·Biochemical and Biophysical Research Communications·J A Nicolette, G C Mueller
Aug 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·W D NOTEBOOM, J GORSKI
Jun 12, 1964·Science·W D WICKS, F T KENNEY
Dec 28, 1964·Annals of the New York Academy of Sciences·L ORNSTEIN

❮ Previous
Next ❯

Citations

Oct 1, 1983·Journal of Steroid Biochemistry·J M Beaumont, J T Knowler
Jan 1, 1980·Journal of Steroid Biochemistry·N Mairesse, P Galand
Dec 1, 1977·General and Comparative Endocrinology·A Gigon-Depeiges, J P Dufaure
Jan 1, 1979·Molecular and Cellular Endocrinology·V L FrobleB Baggett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.