PMID: 6969604Dec 2, 1980Paper

Steroid-induced inhibition of nucleoside uptake in isolated mouse thymocytes

Biochimica Et Biophysica Acta
D GagneD Duval

Abstract

In view of the evidence suggesting a possible effect of high concentrations of steroids on membrane properties, we have investigated the effect of several steroid molecules on the uptake and incorporation of [3H]uridine is isolated mouse thymocytes. Our results demonstrate that the sex steroids, the estrogenic compound, diethylstilbestrol, and several non-hormonal steroid molecules induce a marked inhibition of nucleoside uptake. This effect, which occurs only at concentrations above 10(-6) M, is almost instantaneous but transient and does not therefore appear to be mediated through specific receptor occupancy. Since sex steroids have been shown to inhibit mitogen-induced blast transformation at concentrations close to 10(-5) M, we suggest that this membrane effect of sex steroids may partly explain their immunosuppressive effects.

References

Oct 19, 1978·Nature·E E BaulieuS Schorderet-Slatkine
Mar 11, 1977·Annals of the New York Academy of Sciences·P K SiiteriD Stites
Sep 1, 1979·Journal of Steroid Biochemistry·C J GrossmanP Nathan
Sep 1, 1979·Journal of Steroid Biochemistry·C J GrossmanP Nathan
Jan 31, 1975·Nature·R J Pietras, C M Szego
Dec 1, 1975·Journal of Cellular Physiology·L LackoP Geck
Dec 16, 1974·Biochimica Et Biophysica Acta·P G Plagemann, D P Richey
Jan 31, 1972·Biochemical and Biophysical Research Communications·G W Plagemann, E D Renner
Dec 1, 1973·American Journal of Obstetrics and Gynecology·K G MillarM G Baines
Jul 15, 1972·British Medical Journal·R FinnV Denye
Aug 24, 1972·The New England Journal of Medicine·H N Claman
Jul 1, 1965·Journal of Medicinal Chemistry·R M AtkinsonE G Tomich
Jan 1, 1980·Journal of Steroid Biochemistry·F HomoD Duval
Feb 1, 1980·Journal of Steroid Biochemistry·F HomoC Evrard
Jun 1, 1957·Biochimica Et Biophysica Acta·A MUNCK
Jan 1, 1963·Annual Review of Biochemistry·G M TOMKINS, E S MAXWELL

❮ Previous
Next ❯

Citations

Oct 1, 1993·Cellular and Molecular Neurobiology·M D Fideu, M T Miras-Portugal
Mar 1, 1991·The Journal of Membrane Biology·M TruebaJ M Macarulla
Dec 1, 1981·Journal of Steroid Biochemistry·F HomoF Russo-Marie
Jan 1, 1984·International Journal of Immunopharmacology·S DurantF Homo-Delarche
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D Duval
Dec 23, 1998·Journal of Reproductive Immunology·P J Hansen
Dec 18, 2013·Biochemical and Biophysical Research Communications·Masahiro KanekoShin-Ichiro Takahashi
Jun 1, 2001·Experimental Eye Research·A I Jobling, R C Augusteyn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.