Steroid metabolism in breast cancer: Where are we and what are we missing?

Molecular and Cellular Endocrinology
Donita Africander, Karl-Heinz Storbeck

Abstract

It is well-known that breast cancer is hormone-dependent and that steroid hormones exert their mitogenic effects by binding to estrogen, progesterone and androgen receptors. Vital to our understanding and treatment of this malignancy, is the local metabolism of steroid hormones in breast cancer tissue. This review summarises our current knowledge on steroid producing pathways in the adrenal, ovary and breast, while focussing on the availability of specific circulating hormone precursors and steroidogenic enzymes involved in the local synthesis and metabolism of steroid hormones in the breast. Consequently, we highlight alternate pathways that may be instrumental in the etiology of breast cancer.

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Citations

Apr 11, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yan-Hua BiQing-Zhi Ling
Jun 22, 2018·Molecular and Cellular Endocrinology·Todd K ParsonsYue Wu
Mar 7, 2021·Nutrients·Inmaculada Aguilera-BuenosvinosEstefanía Toledo
Jun 3, 2021·International Journal of Molecular Sciences·Marcela Valko-RokytovskáZuzana Kostecká
May 22, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rachel BleachMarie McIlroy

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