Steroid production by Xenopus ovarian follicles at different developmental stages

Developmental Biology
J E Fortune

Abstract

Xenopus ovarian follicles at different developmental stages were compared with respect to their capacity to produce and secrete steroids and to respond to gonadotropic hormones with changes in steroid production. Individual follicles were obtained by treating ovaries with collagenase and were incubated for 10 hr in incubation medium alone or in medium containing a Xenopus pituitary homogenate (FPH, 0.04 pituitary/ml). At 10 hr oocytes were scored for meiotic maturation and ovulation and incubation media and follicles were collected separately and frozen. Both tissue and media were measured for progesterone, testosterone, and estradiol by radioimmunoassay. The smallest follicles (Dumont Stages I and II) secreted very low or nondetectable levels of these three steroids in both the presence and absence of FPH. Medium-sized follicles (Stages III and IV) were active in secreting estradiol and FPH stimulated a twofold increase in the accumulation of estradiol in the incubation medium. In follicles larger than Stage IV, estradiol secretion decreased as follicular size increased. In contrast, large follicles (Stages V and VI) secreted much more testosterone and progesterone than medium-sized follicles and FPH significantly increased th...Continue Reading

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