Steroid production in testicular tissue of the European eel

Endocrinology
B EcksteinV Hilge

Abstract

Testicular tissue of normal and hCG-stimulated European eels was incubated in vitro with tritiated progesterone or androstenedione as substrates. The following compounds were isolated and identified: 5 beta-androstane-3,17-dione; 17 beta-hydroxy-5 beta-androstan-3-one; androst-4-ene-3,11,17-trione (adrenosterone); 11 beta-hydroxyandrost-4-ene-3,17-dione; 11 beta-hydroxytestosterone; 3 alpha,11 beta-dihydroxy-5 beta-androstan-17-one, and an additional steroid for which the oxidation product was identified as 5 beta-androstene-3,11,17-trione. Four of these steroids have not been hitherto identified in gonadal tissue of any vertebrate. The pattern of steroid production in this tissue is unique for its 5 beta-reduction, for the appearance of adrenosterone as a major metabolite, and for the lack of production of 11-ketotestosterone, which is a regular metabolite of gonadal tissue of teleosts. Thus, it appears that steroid metabolism in the eel testis deviates considerably from the known pattern of steroid production in gonads of other vertebrates.

Citations

Jun 1, 1986·General and Comparative Endocrinology·I A KhanJ Leloup-Hâtey
Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A Rösler
Sep 30, 2005·Food Additives and Contaminants·S PoelmansH F De Brabander
Mar 3, 2005·Development, Growth & Differentiation·Yasuhisa KobayashiMasaru Nakamura
Oct 6, 2015·General and Comparative Endocrinology·Teresa ModestoAdelino V M Canario
Jun 1, 1985·General and Comparative Endocrinology·A R BourneT G Watson

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