PMID: 18407118Nov 1, 1992Paper

Steroid receptor folding by heat-shock proteins and composition of the receptor heterocomplex

Trends in Endocrinology and Metabolism : TEM
W B PrattL C Scherrer

Abstract

Over the past 2 years, reports from several laboratories have supported the proposal that the steroid receptors are bound through the hormone-binding domain to a protein complex that contains three heat-shock proteins-hsp90, hsp70, and hsp56. This receptor-heat-shock-protein heterocomplex accounts for the behavior of the classic 9 S, non-DNA-binding form of the adrenocorticoid, sex hormone, and dioxin receptors. The receptor heterocomplex has now been reconstituted by an enzymatic system in reticulocyte lysate. This represents the first in vitro system for reversing receptor transformation, and this ability to reconstitute the receptor heterocomplex promises rapid advances in our understanding of how these receptors are folded, transported, and regulated by hormone in the cell.

References

Dec 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·W B Pratt
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·W B PrattF C Dalman
May 15, 1991·Biochemical and Biophysical Research Communications·P K Chakraborti, S S Simons
Nov 1, 1990·Molecular Endocrinology·D F SmithD O Toft
Jan 1, 1989·Journal of Steroid Biochemistry·M A Carson-JuricaB W O'Malley
Sep 1, 1989·Molecular and Cellular Biology·S L KostD O Toft
Sep 1, 1987·Journal of Cellular Biochemistry·W B Pratt
Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·D Toft, J Gorski

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Citations

Jun 1, 1994·Biochemical Pharmacology·C D van den KoedijkJ H Thijssen
Feb 1, 1994·Steroids·R B LanzS Rusconi
Sep 13, 1994·Biochimica Et Biophysica Acta·K LisowskaJ Wiśniewski
Jul 1, 1994·Molecular and Cellular Endocrinology·V K PatchevG P Chrousos
May 1, 1995·Trends in Endocrinology and Metabolism : TEM·D P McDonnell
Jun 29, 2013·Biomedical Journal·Jing Li, Johannes Buchner
Sep 18, 1997·Journal of Receptor and Signal Transduction Research·J M HerzG G Yarbrough
Feb 25, 2011·PloS One·Sebastian H ScharfMarianne B Müller
Jul 21, 1998·Annals of the New York Academy of Sciences·I YaharaY Miyata

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