PMID: 2495232Apr 1, 1989Paper

Steroid regulation of monoamine oxidase activity in the adrenal medulla

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
M B YoudimH B Pollard

Abstract

Administration of different steroid hormones in vivo has distinct and specific effects on the MAO activity of the adrenal medulla. In an effort to reconstitute these effects in defined cells, we have isolated endothelial cells and chromaffin cells from the bovine adrenal medulla and tested each cell type for sensitivity to these steroids. As in the intact animal, we found that endothelial cell MAO activity was stimulated 1.5- 2.5-fold by 10 microM progesterone, hydrocortisone, and dexamethasone, inhibited by ca. 50% by 17-alpha-estradiol, but unaffected by testosterone. The type of MAO in the endothelial cells was found to be exclusively of the A type. The chromaffin cells had MAO B exclusively and were inert to treatment with dexamethasone. The mode of action of the various steroids on MAO A activity in endothelial cells seemed to be that of affecting the number of MAO molecules, as binding of [3H]pargyline, an MAO inhibitor, changed in proportion to changes in enzyme activity. Consistently, the kinetic parameters for MAO A showed changes in Vmax but not Km under all conditions. The specificity of steroid action on MAO A activity was also supported by the fact that steroid-induced changes in total cell division ([14C]thymidine...Continue Reading

Citations

Mar 1, 1996·Cell Biochemistry and Function·P CarloG B Picotti
Apr 22, 2008·Addiction·Francesca Ducci, David Goldman
Sep 3, 2014·Reviews in the Neurosciences·Alberto MachadoJosefina Cano
Jan 1, 1990·Critical Reviews in Biochemistry and Molecular Biology·F P Guengerich
Mar 15, 1996·Experientia·A R Ameen
Jun 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irini ManoliMarc R Blackman
Apr 11, 2018·Journal of Neural Transmission·Keith F Tipton
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Nathalie PizzinatAngelo Parini
Mar 23, 2006·Nature Reviews. Neuroscience·Moussa B H YoudimKeith F Tipton
Jan 13, 2021·Ageing Research Reviews·Yohan SantinJeanne Mialet-Perez
Mar 14, 2001·European Journal of Pharmacology·G BompartA Parini
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·Z Q MaA Maggi
Feb 1, 1994·Progress in Neurobiology·M D BerryI A Paterson

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