PMID: 8971906Dec 1, 1996Paper

Steroid-resistant nephrotic focal segmental glomerulosclerosis: a treatable disease

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
B M TuneS A Mendoza

Abstract

If not aggressively treated, oral steroid-resistant (SRst) nephrotic focal segmental glomerulosclerosis (FSGS) is likely to progress to end-stage renal failure. Three observations challenge the conclusion of the International Study of Kidney Diseases in Children (ISKDC) that SRst FSGS is unresponsive to further immunosuppression: (1) The ISKDC definitions of response and relapse, which fit the patterns in minimal change disease, precluded appropriate recognition of partial or gradual responses. (2) In two ISKDC studies, a small number of children with FSGS in one case, and the use of a year of alternate-day prednisone as a control in the other, may have obscured the effects of cyclophosphamide. (3) Recent studies of more aggressive therapies have provided strong evidence of benefit. High-dose methylprednisolone infusion therapy, with alternate-day prednisone alone or with alternate-day prednisone plus an alkylating agent (the M-P/ triple therapy protocol) has achieved sustained, complete remissions with stable renal function in 66% of children with SRst FSGS, and near-complete resolution of proteinuria in another 9%. Cyclosporine (CsA) plus alternate-day prednisone has produced complete or near-complete remissions in 35% of sim...Continue Reading

Citations

May 14, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S MendizábalJ Simon
May 16, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christian PlankUNKNOWN Arbeitsgemeinschaft für Pädiatrische Nephrologie
Jun 21, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mukta MantanArvind Bagga
Oct 15, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Neveen A SolimanGil Chernin
Aug 29, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yuko HamasakiUNKNOWN Japanese Study Group of Renal Disease
Nov 13, 2002·Kidney International·Stephen M Korbet
Mar 18, 2003·Current Opinion in Pediatrics·Corinne Benchimol
Dec 13, 2006·American Journal of Nephrology·Rajendra BhimmaCatherine Connolly
Apr 29, 2003·Paediatric Drugs·Elisabeth Hodson
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A S ChishtiA S Kale
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Guido FillerJanusz Feber
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rashmi KirpekarRichard K Sibley
May 30, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Jei-Wen ChangHsin-Hui Wang
Nov 16, 2004·Revista do Hospital das Clínicas·Emilia Maria Dantas SoeiroYassuhiko Okay
Jan 9, 2019·Kidney Research and Clinical Practice·Mi Young KimHee Gyung Kang
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Elisabeth M HodsonJonathan C Craig
Nov 22, 2019·The Cochrane Database of Systematic Reviews·Isaac D LiuElisabeth M Hodson
Apr 18, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anurag BajpaiRajendra N Srivastava

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
F B WaldoE C Kohaut
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
S A MendozaB M Tune
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
F B WaldoE C Kohaut
© 2021 Meta ULC. All rights reserved