PMID: 7032378Jan 1, 1982

Steroid response in stable chronic obstructive pulmonary disease

Annals of Internal Medicine
L A MendellaN R Anthonisen

Abstract

We compared a 2-week course of 32 mg/d methylprednisolone with placebo in a double-blind crossover trial in 46 well-characterized patients with stable chronic obstructive pulmonary disease. Placebo and steroid trials were separated by 2 weeks when no tablets were given. Response was assessed by measuring forced expiratory volume in 1 second (FEV1.0). Placebo responses were normally distributed (mean, 0.8% change in FEV1.0; range, -30% to 33%). Six patients showed a greater than 50% increase of FEV1.0 in response to steroid; a seventh showed a 36% increase and an eighth, a 29% increase. Because of these patients the group as a whole showed a significantly greater FEV1.0 after steroid than after placebo. The eight steroid responders did not differ from nonresponders in age, sex, smoking history, or duration and intensity of symptoms including wheeze. Baseline lung function and eosinophilia of blood or sputum did not differ between the two groups. Patients who responded to steroids also responded to inhaled beta agonists: Acute bronchodilator response averaged 25% in steroid responders and 13% in nonresponders, a difference that was statistically significant although there was overlap between the two groups.

Citations

Dec 1, 1996·The Annals of Thoracic Surgery·M ArgenzianoM E Ginsburg
Jul 28, 1984·Lancet·D M MitchellJ V Collins
Mar 25, 1999·The New England Journal of Medicine·G W Smetana
Feb 27, 2001·Current Opinion in Pulmonary Medicine·D E Niewoehner
Dec 1, 1994·Journal of Internal Medicine·H O Conn, T Poynard
Sep 25, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·David W ReidE H Walters
Sep 30, 1984·La Clinica terapeutica·R Rudd
Apr 1, 1998·American Journal of Respiratory and Critical Care Medicine·P J BarnesW W Busse
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·E PizzichiniF E Hargreave
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·K L RiceD E Niewoehner
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·Keith L HattotuwaNeil C Barnes
Oct 29, 2010·Annals of Thoracic Medicine·Fahad A Al-Ghimlas, Andrew McIvor
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·R Wood-Baker
Dec 12, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D M Newnham
Jun 1, 1996·Chest·D P Joyce
May 1, 1995·Chest·J Ramsdell
May 1, 1996·Chest·T E RenkemaD S Postma
Jan 30, 1999·Chest·N R Anthonisen
Jun 11, 1998·Mayo Clinic Proceedings·J P UtzC Deschamps
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Rana Y Ali, M Scott Reminick
Nov 14, 1986·The American Journal of Medicine·M S Skorodin
Oct 21, 1991·The American Journal of Medicine·K R Chapman
Sep 1, 1987·Kokyu to junkan. Respiration & circulation·K HosakaY Fukushima
Apr 1, 1985·European Journal of Cancer & Clinical Oncology·J Aisner, M Chatham
Sep 1, 1994·Respiratory Medicine·R IsoahoE Tala
Nov 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·J D CooperS S Lefrak
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Sarah L AppletonNorth West Adelaide Cohort Health Study Team
Jun 4, 2013·Archivos de bronconeumología·Francisco García-RíoSpanish Society of Pulmonology and Thoracic Surgery (SEPAR)
Feb 13, 2001·Pulmonary Pharmacology & Therapeutics·M Rodríguez-CarballeiraL Gómez
Jun 8, 1989·The New England Journal of Medicine·J M Drazen, C Gerard
Dec 11, 2003·São Paulo Medical Journal = Revista Paulista De Medicina·Marcos Eduardo ScheicherElcio Oliveira Vianna
Jan 1, 1986·British Journal of Diseases of the Chest·A G WardmanN J Cooke
Jun 1, 1997·Clinics in Chest Medicine·R D YusenE P Trulock
Jan 10, 2003·The Cochrane Database of Systematic Reviews·F S RamS Cendon
Jul 22, 2005·The Cochrane Database of Systematic Reviews·J A E WaltersR Wood-Baker
Apr 1, 1987·Postgraduate Medicine·W M Alberts, K C Corrigan
Apr 1, 1984·Drug Intelligence & Clinical Pharmacy·M R AlexanderA L Mustion
Jun 1, 1994·Postgraduate Medicine·Michael Jacobs
Jan 1, 1987·Journal of General Internal Medicine·J K StollerA R Feinstein
Aug 1, 1986·Postgraduate Medicine·T L Petty
May 26, 1984·British Medical Journal·R Rudd

Related Concepts

Adrenal Cortex Hormones
Clinical Trials
Double-Blind Method
Eosinophil
Forced Expiratory Volume Function
Differential White Blood Cell Count Procedure
Lung Diseases, Obstructive
Urbason
Cigar smoker

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.