PMID: 9434345Jan 22, 1998Paper

Steroid sex hormones and peripheral arterial disease in the Edinburgh Artery Study

Steroids
J F PriceF G Fowkes

Abstract

Although treatment with high dose exogenous sex hormones affects cardiovascular risk, the role of physiological levels of endogenous sex hormones in the development of atherosclerotic disease in men and women is unknown. Forty men and 43 women wit peripheral arterial disease and 88 age- and sex-matched controls were selected from participants in the Edinburgh Artery Study, a random survey of 1592 men and women ages 55-74 years from the general population. Compared with sex-matched controls, male cases had higher systolic blood pressure (155.5 mmHg vs. 138.7 mmHg; p < or = 0.01) and waist hip ratio (0.92 vs. 0.89; p < or = 0.05) and female cases had higher lifetime smoking (square root of packyears 2.14 vs. 1.03; p < or = 0.05). Mean estrone levels were slightly higher in male cases than controls (101.9 pmol/Liter vs. 92.1 pmol/Liter; p = 0.09), but this association lost significance after multivariate adjustment for age and body mass index. Mean levels of total and free testosterone, estradiol, and sex hormone binding globulin were not significantly different in cases compared with controls in either sex (p > 0.1). These results, in accordance with previous prospective studies on coronary artery disease, do not support a role f...Continue Reading

References

May 13, 1989·BMJ : British Medical Journal·C Bonithon-KoppL Guize
Oct 1, 1987·The American Journal of Cardiology·J A CauleyW S Dai
Nov 4, 1995·BMJ : British Medical Journal·E Barrett-Connor, D Goodman-Gruen
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·M PugeatH Lejeune
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J A CauleyL H Kuller
Apr 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J W YarnellD Riad-Fahmy

❮ Previous
Next ❯

Citations

Nov 15, 2008·European Journal of Nutrition·Bianka DitscheidGerhard Jahreis
Jan 22, 2010·International Journal of Impotence Research·J S Brand, Y T van der Schouw
Jan 23, 2008·Menopause : the Journal of the North American Menopause Society·Rachel P WildmanKim Sutton-Tyrrell
Feb 24, 2009·Stroke; a Journal of Cerebral Circulation·Lynda D LisabethPhilip A Wolf
Feb 28, 2009·Journal of Endocrinological Investigation·S S SignorelliD F Condorelli
Aug 20, 2011·European Journal of Endocrinology·Giovanni CoronaMario Maggi
May 22, 2009·QJM : Monthly Journal of the Association of Physicians·R M ReynoldsB R Walker
Jan 11, 2014·Asian Journal of Andrology·Bu Beng Yeap
Apr 12, 2012·The Journal of Endocrinology·Yasumasa IkedaToshio Matsumoto
Apr 18, 2003·Clinical Endocrinology·Willem de RondeFrank H de Jong
May 18, 2006·Journal of Internal Medicine·J SvartbergE Stensland-Bugge
Feb 18, 2014·Atherosclerosis·Charalambos VlachopoulosChristodoulos Stefanadis
Nov 6, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ian GrahamUNKNOWN European Atherosclerosis Society (EAS)
Nov 1, 2000·The Prostate. Supplement·A W van den Beld, S W Lamberts
Apr 21, 2004·Circulation·Majon MullerYvonne T van der Schouw
Sep 15, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Robert C SpethKathryn Sandberg
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Majon MullerDiederick E Grobbee
Sep 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Johannes B RuigeJean-Marc Kaufman
Oct 25, 2002·Cardiovascular Drug Reviews·Wolfgang Weidemann, Hartmut Hanke
Apr 1, 2019·The American Journal of Cardiology·Kasper AdelborgChristian Fynbo Christiansen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.