Steroid-sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis

Pediatric Pulmonology
Jacquelyn M Zirbes, Carlos E Milla

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is a complication commonly encountered in patients with CF that produces significant respiratory morbidity. Chronic airway colonization with Aspergillus induces strong inflammatory responses with high IgE levels. Current guidelines for therapy include prolonged courses of systemic corticosteroids as the main therapeutic strategy. However this has the potential to induce significant detrimental side effects in children. Omalizumab is a humanized monoclonal antibody directed against IgE that prevents its binding to high- and low-affinity receptors on effector cells. It has been shown to be effective in improving asthma control in patients with a strong allergic component. We present our long term experience with the use of Anti-IgE therapy in three children with CF and ABPA (mean age at start of therapy 14.2 years) who were steroid dependent. All three were already experiencing significant side effects from chronic steroid therapy. After the start of Omalizumab these children have experienced significant and sustained clinical improvements at the same time that they were discontinued from chronic systemic steroids. Our experience suggests that IgE blockade has tremendous potential as...Continue Reading

References

Dec 1, 1992·The Journal of Allergy and Clinical Immunology·R G SlavinC C Tsai
Jul 10, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·E E Leon, T J Craig
Aug 10, 2001·The Journal of Allergy and Clinical Immunology·W BusseN Gupta
Oct 5, 2001·Expert Opinion on Pharmacotherapy·M A Judson, D A Stevens
Mar 1, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William E Berger
Aug 9, 2002·The European Respiratory Journal·R BuhlG Della Cioppa
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David A StevensUNKNOWN Participants in the Cystic Fibrosis Foundation Consensus Conference
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Henry LinThomas B Casale

❮ Previous
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Citations

Jan 19, 2011·Current Allergy and Asthma Reports·Matthias Volkmar Kopp
Jul 27, 2011·Current Allergy and Asthma Reports·Ritesh Agarwal
Aug 20, 2010·Current Opinion in Pulmonary Medicine·Richard B Moss
Apr 5, 2011·Current Opinion in Pulmonary Medicine·Patrick A Flume
Sep 12, 2012·Current Opinion in Pulmonary Medicine·Jennifer J SpeirsJeffrey M Beekman
May 27, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Harshita PantPeter J Macardle
Dec 4, 2012·Journal of Asthma and Allergy·Jennifer CollinsDavid Rosenstreich
Apr 28, 2009·Respiratory Care·Patrick A Flume
Nov 10, 2013·Future Microbiology·Ritesh Agarwal, Arunaloke Chakrabarti
Sep 25, 2010·Revue des maladies respiratoires·P Germaud, A Pipet
Sep 25, 2010·Revue des maladies respiratoires·P Mulliez
Jun 23, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Inderpal RandhawaEliezer Nussbaum
Sep 14, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Robert Y LinGeeta A Bhargave
May 19, 2010·Expert Review of Respiratory Medicine·Jaymin B Morjaria, Riccardo Polosa
Mar 23, 2013·Expert Opinion on Biological Therapy·K Suresh BabuJaymin B Morjaria
Jan 23, 2016·Clinical Reviews in Allergy & Immunology·Stephanie S Eng, Magee L DeFelice
Oct 30, 2012·Immunology and Allergy Clinics of North America·Vincent Cottin, Jean-François Cordier
May 30, 2012·Clinics in Chest Medicine·Sonia N Bains, Marc A Judson
May 28, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M Le BourgeoisJ de Blic
Jan 24, 2012·Allergologia et immunopathologia·J SanchezR Cardona
Oct 29, 2011·The Medical Clinics of North America·Evans R Fernández PérezStephen K Frankel
Dec 3, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Tetsuya HommaMitsuru Adachi
Apr 21, 2009·Clinics in Chest Medicine·Brent P Riscili, Karen L Wood
Apr 22, 2009·Pediatric Pulmonology·Patrick LebecqueCharles Pilette
Jul 31, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R AgarwalUNKNOWN ABPA complicating asthma ISHAM working group
Dec 13, 2012·Annals of the New York Academy of Sciences·Richard B Moss
Jul 31, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C A Callejas, R G Douglas
Jul 27, 2010·Pediatric Pulmonology·Don HayesDavid J Feola
Jan 15, 2014·Pediatric Pulmonology·Brian D KentHarm A W M Tiddens
May 19, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Malena Cohen-CymberknohEitan Kerem
Feb 26, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Yunlian ZhouZhimin Chen
Jun 29, 2015·American Journal of Otolaryngology·Eng Cern GanAmin R Javer
May 25, 2013·Respiratory Medicine·Georgia TunnicliffeFelix Chua
Apr 8, 2009·The Journal of Allergy and Clinical Immunology·Thomas B Casale, Jeffrey Stokes
Dec 3, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Matteo BoniniGiorgio Walter Canonica
Jul 13, 2014·Medicina clínica·Isabel Delgado PecellínCarmen Calero Acuña
Aug 16, 2016·Clinics in Chest Medicine·Vincent Cottin
Oct 8, 2016·Pediatric Pulmonology·Raphaële Nové-JosserandPierre-Régis Burgel
Oct 18, 2016·Expert Review of Respiratory Medicine·Ritesh AgarwalAshutosh N Aggarwal
May 5, 2017·Annals of Thoracic Medicine·Ibrahim Ahmed JanahiAmal Rashid Al-Naimi
Aug 26, 2014·Therapeutic Advances in Respiratory Disease·Sylvia LehmannKlaus Tenbrock
Nov 7, 2015·The Cochrane Database of Systematic Reviews·Kana R JatAnju Khairwa

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.