PMID: 9424402Mar 1, 1997Paper

Steroid therapy in obstructive airway diseases

Respirology : Official Journal of the Asian Pacific Society of Respirology
B Zainudin

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are two common illnesses that cause significant morbidity and mortality. Steroids are widely used in both conditions. They act through steroid or glucocorticoid receptors (GR) causing up or down regulation of protein synthesis resulting in an increase in lipocortin 1 and beta 2 adrenergic receptors, and decreased levels and activities of cytokines or cytokine receptors, which reduces the inflammatory process in the airways and decreases bronchial hyperreactivity. Consequently symptoms of airway obstruction are alleviated and lung function is improved. In asthma, steroids have been convincingly shown to be effective in the treatment of both acute exacerbations and chronic condition. In COPD, however, only a subset of patients seem to respond favourably to steroid therapy. Therapeutic trials are therefore recommended before committing to a long-term treatment in order to determine this subset of patients, as no markers of steroid responsiveness can be identified. The inhaled steroids currently available have a good safety profile with significant side effects occurring only occasionally. Such side effects are usually confined to the oropharynx, causing local irritation, cand...Continue Reading

References

Apr 1, 1977·The Journal of Allergy and Clinical Immunology·J H ToogoodL Chuang
Jun 1, 1979·The Journal of Allergy and Clinical Immunology·A R RooklinH C Mansmann
Jun 1, 1978·The Journal of Allergy and Clinical Immunology·J H ToogoodM Cauchi
Jul 1, 1976·The Journal of Allergy and Clinical Immunology·T NakazawaS Kobayashi
Jan 1, 1976·British Journal of Diseases of the Chest·R F WilleyI W Grant
Nov 1, 1992·The Journal of Allergy and Clinical Immunology·J B WempeD S Postma
Feb 1, 1990·The American Review of Respiratory Disease·J F FisherC L Newman
Jul 20, 1991·BMJ : British Medical Journal·O D Wolthers, S Pedersen
Aug 1, 1991·The Journal of Allergy and Clinical Immunology·S J Szefler
Nov 1, 1991·The Journal of Clinical Investigation·O AyanlarBatumanS A Jimenez
Oct 1, 1990·Thorax·S LorentzsonG Persson
Mar 1, 1991·The Journal of Clinical Endocrinology and Metabolism·A B HodsmanJ C Baskerville
Jun 1, 1991·The American Review of Respiratory Disease·A S VathenenA E Tattersfield
Jun 1, 1991·The American Review of Respiratory Disease·A J WoolcockC M Salome
Jun 1, 1990·Annals of Internal Medicine·L M Stein, R P Cole
Jul 21, 1990·BMJ : British Medical Journal·O D Wolthers, S Pedersen
Nov 1, 1990·Acta paediatrica Scandinavica·J G GleesonJ F Price
Nov 1, 1990·Respiratory Medicine·S M Harding
Jun 16, 1990·BMJ : British Medical Journal·S CapewellA Y Finlay
Jan 1, 1990·The American Review of Respiratory Disease·R J HoppN M Nair
Oct 1, 1989·The American Review of Respiratory Disease·V L CohanR P Schleimer
Oct 7, 1989·BMJ : British Medical Journal·A E Davies, R W Davey
Oct 7, 1989·BMJ : British Medical Journal·A K KarimT J Jacob
Dec 1, 1986·The Journal of Clinical Investigation·A J WardlawA B Kay
Jan 1, 1988·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S M SchneiderC H Harcup

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Citations

Sep 6, 2000·Journal of Clinical Pharmacy and Therapeutics·E SapeyM J Kendall
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·M Z NorzilaP G Gibson
Feb 1, 2017·Expert Review of Respiratory Medicine·Mario CazzolaMaria Gabriella Matera
Jun 3, 2010·The Journal of International Medical Research·M HuertaB Trujillo-Hernández
Jul 26, 2006·Respiration; International Review of Thoracic Diseases·Demet KarnakAtul C Mehta
Oct 2, 2019·Plant Disease·Abraham M FulmerEmily G Cantonwine

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