PMID: 8956488Jan 1, 1996Paper

Steroid transformation by mutants of Mycobacterium sp. with altered response to antibiotics

Journal of Basic Microbiology
S BarthakurA C Ghosh

Abstract

Mycobacterium sp. NRRLB3683 which is capable to convert beta-sitosterol to 1,4-androstadiene-3,17-dione (ADD) was treated with methyl methane sulfonate and two strains with altered sensitivity to various antibiotics were obtained. One of the strain was steroid 1(2)-dehydrogenase negative and the other positive. Efficiency of utilization of sterols followed the order beta-sitosterol > cholesterol > soluble cholesterol. The steroid 1(2)-dehydrogenase negative strain was capable of producing 17KS (AD) from beta-sitosterol and converting AD to testosterone and ADD to AD suggesting the negative role of 1(2)-dehydrogenase in sterol side chain cleavage and decrease in hydrogenase activity by mutation. But this enzyme can perform the reverse reaction under aerobic condition.

References

Jan 1, 1977·Advances in Applied Microbiology·C K Martin
Sep 28, 1979·Biochimica Et Biophysica Acta·M G WovchaL A Kominek
Jan 1, 1985·Journal of Basic Microbiology·K Kieslich

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Citations

Jan 14, 2005·Applied Microbiology and Biotechnology·M V DonovaI F Puntus
Jun 15, 2011·Applied Microbiology and Biotechnology·Wenquan ZhangHongzhong Wang
Aug 7, 2002·The Journal of Steroid Biochemistry and Molecular Biology·O V EgorovaM V Donova
Jun 19, 2004·Food Additives and Contaminants·H F De BrabanderK De Wasch
Dec 19, 2007·Rapid Communications in Mass Spectrometry : RCM·Francesco ArioliGiuseppe Pompa
Mar 15, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Luca ChiesaFrancesco Arioli
Mar 10, 2007·Prikladnaia biokhimiia i mikrobiologiia·M V Donova
May 4, 2020·Steroids·Krishika Sambyal, Rahul Vikram Singh

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