PMID: 7546561Sep 1, 1995Paper

Steroidal glycosides from Allium macleanii and A. senescens, and their inhibitory activity on tumour promoter-induced phospholipid metabolism of HeLa cells

Phytochemistry
T InoueH Nishino

Abstract

A new polyhydroxylated cholestane trisdesmoside and a new spirostanol pentasaccharide, together with five known spirostanol saponins, were isolated from the bulbs of Allium macleanii, and two known spirostanol saponins were isolated from the bulbs of A. senescens. The identification and structural assignments of the steroidal glycosides were performed by spectroscopic analysis and hydrolysis. Furthermore, the isolated compounds were evaluated for inhibitory activity on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32P-incorporation into phospholipids of HeLa cells, which is recognized as an excellent primary screening test to identify new antitumour-promoter compounds.

Citations

May 9, 2002·Biological & Pharmaceutical Bulletin·Balik DzhambazovNikola Popov
Feb 24, 2001·Drug Metabolism and Drug Interactions·A V Rao, D M Gurfinkel
Feb 5, 2013·Natural Product Reports·Victoria L Challinor, James J De Voss
Feb 20, 2016·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Danuta SobolewskaKarolina Grabowska
Mar 29, 2011·Phytochemistry·Jacqueline EskanderDominique Harakat
Jul 7, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Zhihui YuLiqiu Xia
Jul 12, 2002·Rapid Communications in Mass Spectrometry : RCM·Feng LiangJian-gong Shi
Jun 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mubasher HussainDongliang Qiu
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Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiyeon KimSoon Ae Kim
Nov 19, 2009·Journal of Agricultural and Food Chemistry·Jan KustererMichael Keusgen

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