Steroidal pyrazolines evaluated as aromatase and quinone reductase-2 inhibitors for chemoprevention of cancer

International Journal of Biological Macromolecules
Mohamed M AbdallaAbdullah M Al-Mohizea

Abstract

The aromatase and quinone reductase-2 inhibition of synthesized heterocyclic pyrazole derivatives fused with steroidal structure for chemoprevention of cancer is reported herein. All compounds were interestingly less toxic than the reference drug (Cyproterone(®)). The aromatase inhibitory activities of these compounds were much more potent than the lead compound resveratrol, which has an IC(50) of 80 μM. In addition, all the compounds displayed potent quinone reductase-2 inhibition. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). The aromatase and quinone reductase-2 inhibitors resulting from this study have potential value in the treatment and prevention of cancer.

References

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Citations

Dec 11, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A BahashwanAtef Kalmouch
Nov 19, 2014·International Journal of Molecular Sciences·Huiding XieXiaoguang Xie
May 15, 2012·International Journal of Biological Macromolecules·Saleh A BahashwanIbrahim M S Bassati
May 1, 2012·International Journal of Biological Macromolecules·Mohamed M AbdallaNermien M Sabrye
Apr 23, 2013·International Journal of Biological Macromolecules·Amer M AlanaziAbd El-Galil E Amr
Mar 19, 2013·International Journal of Biological Macromolecules·Naif O Al-HarbiAbd El-Galil E Amr
Dec 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Osama I Abd El-SalamAbd El-Galil E Amr
Mar 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed El-NaggarMohamed A Al-Omar
Oct 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandra Cortés-PercinoSara Montiel-Smith
Jan 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abd El-Galil E AmrMohamed M Abdallah
Apr 23, 2020·Future Medicinal Chemistry·Ranju Bansal, Ranjit Singh
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shaza M ElhusseinyKhaled M Aboshanab

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