Steroidal saponins from Myriopteron extensum and their cytotoxic activity

Planta medica
Ming-Fu YangGuo-Lin Zhang

Abstract

Two new steroidal saponins, extensumsides A ( 1) and B ( 2), were isolated from the whole plants of Myriopteron extensum (Wight) K. Schum. Their structures were elucidated as 17 beta-uzarigenin-3- O- beta-glucopyranosyl-(1-->6)- beta-glucopyranosyl-(1-->4)- beta-thevetopyranosyl-(1-->4)- beta-cymaropyranoside ( 1) and 12-(3-methylbut-2-enoyloxy)pregn-5-en-20-one 3- O-[beta-cymaropyranosyl-(1-->4)-beta-cymaropyranosyl-(1-->4)-beta-thevetopyranosyl-(1-->4)-(6- O-sulfo-beta-glucopyranoside)] ( 2) on the basis of chemical and spectral evidence. Extensumside A exhibited significant cytotoxicity against eight cancer cell lines with a mean GI (50) value of 0.346 microg/mL.

Citations

Jun 17, 2010·Fitoterapia·Shuli ManChangxiao Liu
Sep 14, 2016·Journal of Asian Natural Products Research·Xue-Mei LiZi-Chao Mao
Nov 20, 2014·Natural Product Reports·John P Munafo, Thomas J Gianfagna
Sep 30, 2005·Natural Product Reports·James R Hanson
Nov 16, 2012·Natural Product Reports·Jorge A R SalvadorM Luisa Sá e Melo
Jan 8, 2008·Journal of Natural Products·George R PettitJean-Charles Chapuis
Dec 15, 2016·Journal of Agricultural and Food Chemistry·Guo SunZhi-Zhi Du

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