PMID: 11324711Apr 28, 2001Paper

Steroidogenic correlates of pregnancy in the rock hyrax (Procavia capensis)

Life Sciences
S KirkmanH C Potgieter

Abstract

In pregnant rock hyraxes isolated leucocytes metabolise both [3H]pregnenolone and [3H]progesterone while whole blood, erythrocytes and an erythrocyte/leucocyte mixture only metabolised [3H]progesterone. Plasma displayed no tendency to metabolically convert any one of these two steroids. In whole blood [3H]progesterone appears to be converted to 5alpha-pregnane-3,20-dione and a compound with chromatographic properties similar to that of 5alpha-pregnan-3alpha-ol-20-one. 5Alpha-pregnane-3,20-dione exhibited a high relative binding affinity for the uterine progesterone eceptor (94%), but 5alpha-pregnan-3alpha-ol-20-one displayed very little affinity for the same receptor (0.4%). 5Alpha-pregnane-3,20-dione may therefore aid in the maintenance of pregnancy. Corpora lutea metabolised progesterone to 17alpha-hydroxyprogesterone, a compound exhibiting no progestational function because of its low relative binding affinity for the uterine progesterone receptor (2%). Progesterone appears to be the main product of the corpus luteum. However, 5alpha-pregnane-3,20-dione circulated at concentrations approximately 8.5 times higher than progesterone, probably due to the metabolic conversion of progesterone to 5alpha-pregnane-3,20-dione by the b...Continue Reading

Citations

Nov 30, 2005·Hormones and Behavior·Lee KorenEli Geffen
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth L ScholtzAlan J Conley
May 14, 2016·Theriogenology·S BairagiL P Reynolds
Apr 19, 2018·Biology of Reproduction·Lawrence P ReynoldsAlan J Conley
Jun 2, 2018·The Journal of Endocrinology·A J ConleyS D Stanley
Jun 17, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Anneke MorescoDalen W Agnew

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