Abstract
The expression of the prolactin receptor is under the control of two putative tissue-specific (PI, gonads; PII, liver) and one common (PIII) promoters (Hu, Z. Z., Zhuang, L., and Dufau, M. L. (1996) J. Biol. Chem. 271, 10242-10246). The three promoter regions were co-localized to the rat chromosomal locus 2ql6, in the order 5'-PIII-PI-PII-3'. To investigate the mechanisms of gonad-specific utilization of PI, the promoter domain, regulatory cis-elements, and trans-factors were identified in gonadal cells. The promoter domain localized to the 152-base pair 5' of the transcriptional start site at -549 is highly active in gonadal cells but has minimal activity in hepatoma cells. It contains a steroidogenic factor 1 (SF-1) element (-668) that binds the SF-1 protein of nuclear extracts from gonadal cells and is essential for promoter activation. A CCAAT box (-623) contributes minimally to basal activity in the absence of the SF-1 element, and two adjacent TATA-like sequences act as inhibitory elements. Thus, PI belongs to a class of TATA-less/non-initiator gene promoters. These findings demonstrate an essential role for SF-1 in transcriptional activation of promoter I of the prolactin receptor gene, which may explain the tissue-speci...Continue Reading
References
Nov 27, 1991·Biochemical and Biophysical Research Communications·Z Z Hu, M L Dufau
Aug 1, 1990·Analytical Biochemistry·J Alam, J L Cook
Mar 30, 1990·Biochimica Et Biophysica Acta·R Leventis, J R Silvius
Jan 1, 1989·Annual Review of Biochemistry·P F Johnson, S L McKnight
Apr 8, 1988·Cell·L A ChodoshP A Sharp
Jul 1, 1982·The Journal of Cell Biology·R V Rebois
Feb 1, 1984·Endocrinology·D R Aquilano, M L Dufau
Jul 1, 1994·Genomics·X Y GuanJ M Trent
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·U WehrenbergN Walther
May 20, 1994·Cell·X LuoK L Parker
Jun 3, 1994·Cell·W H ShenH A Ingraham
Sep 1, 1993·Molecular and Cellular Biology·T E WilsonJ Milbrandt
Apr 26, 1996·The Journal of Biological Chemistry·Z HuM L Dufau
Feb 16, 1996·The Journal of Biological Chemistry·S OsadaM Imagawa
Mar 22, 1996·The Journal of Biological Chemistry·L M HalvorsonW W Chin
Dec 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K I Morohashi, T Omura
Jan 1, 1997·Biology of Reproduction·D L DuvalC M Clay
Citations
Nov 19, 2003·Biochemical and Biophysical Research Communications·Fan WuQiangHajime Nawata
Oct 22, 2003·Molecular Genetics and Metabolism·Robert Clipsham, Edward R B McCabe
Dec 13, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Mark P LeondiresMaria L Dufau
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·Z Z HuM L Dufau
Dec 9, 2000·Biochimica Et Biophysica Acta·K SchoonjansJ Auwerx
Mar 31, 1999·DNA and Cell Biology·P ZhangS H Mellon
Jun 24, 1998·Genes & Development·T N SeagrovesJ M Rosen
Sep 16, 2003·Molecular and Cellular Biology·Ying Zhang, Maria L Dufau
Sep 2, 2005·Molecular and Cellular Biology·Ying ZhangMaria L Dufau
Nov 5, 2003·Nuclear Receptor·Pierre ValAntoine Martinez
Feb 2, 2012·Journal of Molecular Endocrinology·Hidemi TabataMinoru Tanaka
Apr 12, 2013·Journal of Molecular Endocrinology·Anke SchenninkRussell C Hovey
Jan 30, 2013·Experimental Animals·Junko HiraiMinoru Tanaka
Mar 24, 2009·Fertility and Sterility·Alexandre Guilherme Zabeu RossiEdmund C Baracat
Jul 11, 2007·Journal of Neuroendocrinology·H NogamiS Hisano
Feb 17, 2015·General and Comparative Endocrinology·Guixian BuYajun Wang
Mar 19, 2013·Molecular and Cellular Endocrinology·Guixian BuYajun Wang
Aug 6, 1999·Frontiers in Neuroendocrinology·G D Hammer, H A Ingraham
Oct 24, 2007·Molecular and Cellular Endocrinology·Srinivasan Rengarajan, Karundevi Balasubramanian
Feb 24, 2001·Biology of Reproduction·P de Santa BarbaraB Boizet-Bonhoure
Jul 14, 2017·PLoS Genetics·Syed Abbas BukhariAlison M Bell
Nov 30, 2006·Journal of Cellular Biochemistry·Rody San MartínManuel Krauskopf
Mar 6, 1999·Endocrinology·J N MaoL A Cogburn
May 22, 2002·Endocrinology·Minoru TanakaKunio Nakashima
Jun 29, 1999·Endocrinology·D LopezM P McLean
Dec 7, 2000·Endocrinology·D BoerboomJ Sirois
May 3, 2006·The Journal of Biological Chemistry·Juying DongMaria L Dufau
Aug 2, 2001·The Journal of Biological Chemistry·A L JacobL Hedin
Dec 23, 1999·The Journal of Biological Chemistry·P Z TangM L Dufau
Sep 25, 1998·The Journal of Biological Chemistry·Z Z HuM L Dufau
May 30, 1998·Molecular Endocrinology·S ZimmermannI M Adham
Oct 30, 2001·Molecular Endocrinology·Y Zhang, M L Dufau
Dec 20, 2007·Endocrine Research·Momoko KobayashiMinoru Tanaka
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Jun 22, 1999·The Journal of Biological Chemistry·E D GalsgaardA Møldrup
May 5, 1998·Molecular and Cellular Biology·P A CrawfordJ Milbrandt