Steroidogenic factor-1 is an essential transcriptional activator for gonad-specific expression of promoter I of the rat prolactin receptor gene.

The Journal of Biological Chemistry
Z Z HuM L Dufau

Abstract

The expression of the prolactin receptor is under the control of two putative tissue-specific (PI, gonads; PII, liver) and one common (PIII) promoters (Hu, Z. Z., Zhuang, L., and Dufau, M. L. (1996) J. Biol. Chem. 271, 10242-10246). The three promoter regions were co-localized to the rat chromosomal locus 2ql6, in the order 5'-PIII-PI-PII-3'. To investigate the mechanisms of gonad-specific utilization of PI, the promoter domain, regulatory cis-elements, and trans-factors were identified in gonadal cells. The promoter domain localized to the 152-base pair 5' of the transcriptional start site at -549 is highly active in gonadal cells but has minimal activity in hepatoma cells. It contains a steroidogenic factor 1 (SF-1) element (-668) that binds the SF-1 protein of nuclear extracts from gonadal cells and is essential for promoter activation. A CCAAT box (-623) contributes minimally to basal activity in the absence of the SF-1 element, and two adjacent TATA-like sequences act as inhibitory elements. Thus, PI belongs to a class of TATA-less/non-initiator gene promoters. These findings demonstrate an essential role for SF-1 in transcriptional activation of promoter I of the prolactin receptor gene, which may explain the tissue-speci...Continue Reading

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Citations

Nov 19, 2003·Biochemical and Biophysical Research Communications·Fan WuQiangHajime Nawata
Oct 22, 2003·Molecular Genetics and Metabolism·Robert Clipsham, Edward R B McCabe
Dec 13, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Mark P LeondiresMaria L Dufau
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·Z Z HuM L Dufau
Dec 9, 2000·Biochimica Et Biophysica Acta·K SchoonjansJ Auwerx
Nov 5, 2003·Nuclear Receptor·Pierre ValAntoine Martinez
Apr 12, 2013·Journal of Molecular Endocrinology·Anke SchenninkRussell C Hovey
Mar 24, 2009·Fertility and Sterility·Alexandre Guilherme Zabeu RossiEdmund C Baracat
Feb 17, 2015·General and Comparative Endocrinology·Guixian BuYajun Wang
Aug 6, 1999·Frontiers in Neuroendocrinology·G D Hammer, H A Ingraham
Nov 30, 2006·Journal of Cellular Biochemistry·Rody San MartínManuel Krauskopf
Dec 23, 1999·The Journal of Biological Chemistry·P Z TangM L Dufau
May 30, 1998·Molecular Endocrinology·S ZimmermannI M Adham
Oct 30, 2001·Molecular Endocrinology·Y Zhang, M L Dufau
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
May 5, 1998·Molecular and Cellular Biology·P A CrawfordJ Milbrandt

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