PMID: 7517064Jun 1, 1994Paper

Steroidogenic impairment after lindane treatment in male rats

Journal of UOEH
A R Chowdhury, A K Gautam

Abstract

The effect on testicular steroidogenesis after lindane (delta-isomer of hexachlorocyclohexane) administration of 4 and 8 mg/kg, i.p. daily for 45 days to male mature rats was investigated. A significant decline in testicular weight of both test groups was observed. Cellular degeneration in Leydig cells of the 8 mg/kg treated group was conspicuous. A sharp decline in the Leydig cell's population and morphological deformation were supported by the decreased activities of testicular hyaluronidase and 3 beta delta 5-hydroxysteroid dehydrogenase. A high level of testicular cholesterol and depletion of ascorbic acid were also responsible for steroidogenic impairment in the treated groups. These impairments also led to a significant diminution in serum testosterone.

Citations

May 8, 1998·Bioscience, Biotechnology, and Biochemistry·S YoshidaK Takeda
Feb 24, 2006·American Journal of Epidemiology·Sherry L FarrGlinda S Cooper
Feb 18, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gina La SalaMassimo De Felici
Dec 6, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leping YeRen-Shan Ge

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