PMID: 15253326Jul 16, 2004Paper

Steroids and antibiotics for treatment of acute asthma exacerbations in African-American children

Journal of the National Medical Association
Rui G Rodrigues

Abstract

There has been great debate surrounding the appropriate treatment regimens in children who present with acute asthma exacerbations secondary to upper respiratory tract infections. To determine whether treatment with corticosteroids alone or in combination with antibiotics will decrease respiratory symptoms in children who develop asthma exacerbations secondary to upper respiratory tract infections. A retrospective cohort control study involving 86 African-American children, ages 5-16, with mild intermittent asthma. The patients were treated with an albuterol inhaler (control group), inhaler plus five days of Prednisone; or inhaler, Prednisone, and 10 days of Amoxicillin. All patients were assessed regarding peak flows, albuterol inhaler usage, and symptomatology. On follow up five- to seven days after presentation, the corticosteroids group demonstrated a marked improvement in peak flows (88% versus 77%) and a significantly lower albuterol inhaler usage rate (2.2 versus 3.7 times a day) relative to the control group. The corticosteroids plus antibiotics group demonstrated peak flows (86% versus 88%) and inhaler usage (2.4 versus 2.2) nearly identical to corticosteroids alone, but the severity of underlying respiratory symptoms ...Continue Reading

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