Steroids and the secretory function of the exocrine pancreas

Endocrinology
A R BeaudoinA Grossman

Abstract

The influence of steroids on the exocrine pancreas of male rats was examined by removing steroid producing tissue and by introducing individual steroids into these animals at a later date. Castration had no demonstrable morphological effect on acinar cells, whereas castration combined with adrenalectomy caused a marked depletion of zymogen granules as well as widening of peri- and interlobular spaces. Treatment of castrated-adrenalectomized rats with estradiol restored a normal appearance of the pancreas within about 9 h. Triamcinolone acetonide produced similar results. These morphological changes were accompanied by significant alterations of the relative amounts of digestive enzymes present in zymogen granules. A marked reduction of amylase occurred in the castrated-adrenalectomized group. Neither estradiol nor triamcinolone could reverse these effects within 9 h. Castration alone had no significant effect on the relative proportion of amylase; however, it increased the relative amount of proteases. This effect was reversed by estradiol treatment. Estradiol also induced significant changes in the proportion of proelastase in castrated-adrenalectomized animals. Replacement therapy in castrated-adrenalectomized rats with dexam...Continue Reading

Citations

Feb 15, 1997·Microscopy Research and Technique·G GrondinD Lebel
Sep 1, 1987·Journal of Steroid Biochemistry·A GrossmanJ F Morris
Dec 1, 1989·Journal of Steroid Biochemistry·P AllietP C Lee
Jun 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M A MansoI de Dios
Dec 1, 1990·Baillière's Clinical Gastroenterology·A Andrén-Sandberg, P L Bäckman
Dec 24, 1997·Molecular and Cellular Endocrinology·A C García-MonteroI de Dios
Aug 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·M A MansoI De Dios
Jun 3, 1999·European Journal of Clinical Investigation·A C García-MonteroI De Dios
Nov 15, 2000·Pancreas·D SanchezO Guy-Crotte
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·I HilgendorfC Kruse
Dec 1, 1990·Archives internationales de physiologie et de biochimie·I de DiosM A López
Aug 1, 1988·Biochemical Medicine and Metabolic Biology·I de DiosJ J Calvo
Apr 30, 1992·Biochemical and Biophysical Research Communications·L LaforestA R Beaudoin
Nov 14, 1998·The American Journal of Physiology·G T BlevinsS T Miller
Apr 26, 2021·Cellular and Molecular Gastroenterology and Hepatology·Melinda WangAditi Bhargava
Oct 1, 1992·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J GauvreauA R Beaudoin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.