Abstract
Chronic obstructive pulmonary disease (COPD) is characterised by neutrophilic inflammation in the airways and these neutrophils contribute to the production of inflammatory mediators. Dampening the production of proinflammatory mediators might be an important strategy to treat COPD and glucocorticosteroids are known to do so via inhibition of nuclear factor-κB. However, this pathway is important for the control of pro- and anti-inflammatory genes. We studied the effects of dexamethasone on production and secretion of pro-inflammatory interleukin (IL)-1β and anti-inflammatory secreted IL-1 receptor antagonist (sIL-1Ra) by human neutrophils activated with tumor necrosis factor (TNF)-α. In vitro, TNF-α-stimulated neutrophils produced significant amounts of IL-1β and sIL-1Ra; this production was inhibited by dexamethasone. However, synthesis and secretion of sIL-1Ra was inhibited at lower concentrations dexamethasone compared to IL-1β, which changed the IL-1β:sIL-1Ra ratio significantly. This altered ratio resulted in a more pro-inflammatory condition, as visualised by increased intercellular adhesion molecule-1 expression on human endothelial cells. In vivo, moderate-to-severe COPD patients using inhaled glucocorticosteroids have ...Continue Reading
Citations
Sep 8, 2011·BMC Pulmonary Medicine·Jeroen D LangereisLaurien H Ulfman
Sep 18, 2012·PloS One·Gaelle HirschJean-Pierre Lavoie
Feb 25, 2014·PloS One·Lydia E Haddad, Martin G Sirois
Jun 7, 2014·PloS One·Delphine LabrousseThomas Henry
Nov 10, 2012·American Journal of Epidemiology·Carlos IribarrenMark D Eisner
Mar 24, 2016·Critical Care : the Official Journal of the Critical Care Forum·Pieter H C LeliefeldJanesh Pillay
Jun 19, 2016·BMC Veterinary Research·Simon RüttenWieland Schrödl
Mar 3, 2017·Nursing Research·Shannon L GillespiePamela J Salsberry
Mar 31, 2016·Molecular & Cellular Proteomics : MCP·Astrid SlanyChristopher Gerner
Dec 20, 2018·International Journal of Molecular Sciences·Simona RonchettiCarlo Riccardi
Apr 23, 2013·Shock·Falco HietbrinkLuke P H Leenen
Mar 30, 2017·Frontiers in Immunology·Anastasia PolycarpouDiana N J Lockwood
Jun 1, 2018·Journal of Immunology Research·A KovtunA Ignatius
Dec 20, 2013·Journal of Diabetes Science and Technology·Ulrike KluehDonald L Kreutzer
Jan 11, 2020·Frontiers in Immunology·Gianluigi ZazaPaolo Cravedi
Sep 16, 2020·Reproduction in Domestic Animals = Zuchthygiene·Fika Yuliza PurbaNaoki Isobe
Nov 10, 2020·Frontiers in Pharmacology·Chih-Chao ChiangTsong-Long Hwang
Apr 6, 2019·Veterinary Immunology and Immunopathology·Simon RüttenGetu Abraham