Steroids make you bigger? Fat chance says Myc.

Cell Metabolism
Akhila Rajan, Norbert Perrimon

Abstract

In flies, ecdysone integrates growth with developmental transitions by antagonizing insulin signaling, which links growth with nutritional status. Work in Developmental Cell (Delanoue et. al, 2010) finds that ecdysone represses the transcription factor Myc in the larval fat body to inhibit systemic growth, revealing a mechanism for such coordination.

References

Sep 28, 1999·Cell·L A JohnstonP Gallant
Sep 25, 2003·Cell·Julien ColombaniPierre Léopold
Sep 24, 2005·Science·Julien ColombaniPierre Léopold

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