PMID: 11915938Mar 28, 2002Paper

Sterol carrier protein-2: structure reveals function

Cellular and Molecular Life Sciences : CMLS
N StolowichF Schroeder

Abstract

The multiple actions of sterol carrier protein-2 (SCP-2) in intracellular lipid circulation and metabolism originate from its gene and protein structure. The SCP-x/pro-SCP-2 gene is a fusion gene with separate initiation sites coding for 15-kDa pro-SCP-2 (no enzyme activity) and 58-kDa SCP-x (a 3-ketoacyl CoA thiolase). Both proteins share identical cDNA and amino acid sequences for 13-kDa SCP-2 at their C-termini. Cellular 13-kDa SCP-2 derives from complete, posttranslational cleavage of the 15-kDa pro-SCP-2 and from partial posttranslational cleavage of 58-kDa SCP-x. Putative physiological functions of SCP-2 have been proposed on the basis of enhancement of intermembrane lipid transfer (e.g., cholesterol, phospholipid) and activation of enzymes involved in fatty acyl CoA transacylation (cholesterol esters, phosphatidic acid) in vitro, in transfected cells, and in genetically manipulated animals. At least four important SCP-2 structural domains have been identified and related to specific functions. First, the 46-kDa N-terminal presequence present in 58-kDa SCP-x is a 3-ketoacyl-CoA thiolase specific for branched-chain acyl CoAs. Second, the N-terminal 20 amino acid presequence in 15-kDa pro-SCP-2 dramatically modulates the se...Continue Reading

Citations

Jun 28, 2005·Journal of Molecular Evolution·Juli PeretóDavid Moreira
Feb 28, 2006·Journal of Molecular Evolution·Johan Edqvist, Kristina Blomqvist
Oct 6, 2010·Journal of Structural and Functional Genomics·Alexander K GoroncyShigeyuki Yokoyama
Jun 10, 2008·Lipids·Avery L McIntoshFriedhelm Schroeder
May 10, 2008·Biochemistry·Gregory G MartinFriedhelm Schroeder
May 20, 2005·The Journal of Biological Chemistry·Margarita L MalakhovaRhoderick E Brown
Mar 18, 2004·Antioxidants & Redox Signaling·Albert W Girotti, Tamas Kriska
Jan 10, 2012·Journal of Lipid Research·Avery L McIntoshFriedhelm Schroeder
Sep 13, 2011·International Journal for Parasitology·Muriel MazetPaul A M Michels
Jun 12, 2010·The Journal of Nutritional Biochemistry·Barbara P AtshavesFriedhelm Schroeder
Apr 21, 2009·Biochimica Et Biophysica Acta·Noelia I BurgardtMarcelo Ceolín
Jan 29, 2008·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Xun HuangLawrence I Gilbert
Nov 7, 2015·Archives of Biochemistry and Biophysics·Gregory G MartinFriedhelm Schroeder
Apr 10, 2007·Archives of Biochemistry and Biophysics·Will A StanleyMatthias Wilmanns
Jun 5, 2007·Biochimica Et Biophysica Acta·Friedhelm SchroederAnn B Kier
Mar 23, 2007·Analytical Biochemistry·Robert M Kernstock, Albert W Girotti
Aug 8, 2006·Archives of Biochemistry and Biophysics·Raúl G FerreyraMario R Ermácora
Oct 7, 2004·Biochimica Et Biophysica Acta·Sushmita Mukherjee, Frederick R Maxfield
Jan 19, 2013·Microbiology·Robert W Murdoch, Anthony G Hay
Jun 28, 2015·Archives of Biochemistry and Biophysics·Gregory G MartinAnn B Kier
Oct 10, 2006·Biochimica Et Biophysica Acta·Yves PoirierJ Kalervo Hiltunen
Sep 23, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·L M CurtoJ M Delfino
Feb 11, 2018·Cellular and Molecular Life Sciences : CMLS·Ana L Santos, Giulio Preta
Jun 14, 2018·The New Phytologist·Sina KrombachRegine Kahmann
Mar 31, 2005·The Journal of Biological Chemistry·Hui ZhengYves L Marcel
Jan 31, 2006·Molecular and Cellular Biochemistry·Daniel G MilisJohn R Jefferson
Mar 9, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Jing GongQing-You Xia
Oct 4, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gregory G MartinFriedhelm Schroeder
May 20, 2004·The Biochemical Journal·Adalberto M GallegosFriedhelm Schroeder
Jun 30, 2005·The Biochemical Journal·Gregory G MartinFriedhelm Schroeder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.