Sterol metabolism in the rat: effect of alcohol on sterol metabolism in two strains of rats

Alcoholism, Clinical and Experimental Research
B I Cohen, R F Raicht

Abstract

Sterol metabolism studies using a combination of isotopic and chromatographic procedures were carried out in two strains of rats fed 5% ethanol (36% of calories) in the diet. Feeding ethanol to the Fisher rat over 17 days produced no significant changes in body weight. Cholesterol levels in various tissues were elevated in the ethanol-fed group: plasma cholesterol, +61%; liver cholesterol, +47%; and bile cholesterol, +57%. The alcohol-fed Fisher rat showed several changes in sterol metabolism over controls: fecal acidic steroid output, +13%; fecal neutral sterol output, +51%; endogenous neutral sterol output, +107%; cholesterol turnover, +54%; and cholesterol balance, +18%. Ethanol feeding to the Sprague Dawley rat showed similar differences between ethanol-fed vs. control rats. Cholesterol levels were significantly elevated in plasma (+35%) and in the liver (+81%). Sterol metabolism data showed the following differences (alcohol vs. control): fecal acidic steroid output, +9%; fecal neutral sterol output, +17%; endogenous neutral sterol output, +72%; cholesterol turnover, +33%; and cholesterol balance +13%. The Fisher rat maintained almost constant weight throughout the experimental period and is a preferable strain for sterol ...Continue Reading

References

Apr 1, 1970·The Journal of Clinical Investigation·E Baraona, C S Lieber
Jun 1, 1965·The Journal of Clinical Investigation·C S LIEBERL M DECARLI

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·C S Lieber
Jun 12, 2003·Life Sciences·Hyun-Ju SeoMyung-Sook Choi
Jan 1, 1997·Addiction Biology·H Seitz, G Poschl
Mar 1, 1985·The Journal of Clinical Investigation·C KarsentyC S Lieber
Jul 1, 1984·Alcoholism, Clinical and Experimental Research·C S Lieber, M Savolainen
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·C S Lieber
Jun 9, 1998·Cancer Detection and Prevention·S I Mufti

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