PMID: 11607106Oct 1, 1990Paper

Sterol phylogenesis and algal evolution

Proceedings of the National Academy of Sciences of the United States of America
W D NesE R Katz

Abstract

The stereochemistry of several sterol precursors and end products synthesized by two fungal-like micro-organisms Prototheca wickerhamii (I) and Dictyostelium discoideum (II) have been determined by chromatographic (TLC, GLC, and HPLC) and spectral (UV, MS, and 1H NMR) methods. From I and II the following sterols were isolated from the cells: cycloartenol, cyclolaudenol, 24(28)-methylenecycloartanol, ergosterol, protothecasterol, 4alpha-methylergostanol, 4alpha-methylclionastanol, clionastanol, 24beta-ethylcholesta-8,22-enol, and dictyosterol. In addition, the mechanism of C-24 methylation was investigated in both organisms by feeding to I [2-3H]lanosterol, [2-3H]cycloartenol, [24-3H]lanosterol, and [methyl-2H3]methionine and by feeding to II [methyl-2H3]methionine. The results demonstrate that the 24beta configuration is formed by different alkylation routes in I and II. The Delta25(27) route operates in I while the Delta24(28) route operates in II. Based on what is known in the literature regarding sterol distribution and phylogenesis together with our findings that the stereochemical outcome of squalene oxide cyclization leads to the production of cycloartenol rather than lanosterol (characteristic of the fungal genealogy) an...Continue Reading

References

Sep 1, 1978·Scientific American·J W Schopf
May 11, 1989·Nature·R PerassoA Adoutte
Jan 1, 1987·Annual Review of Microbiology·G OurissonK Poralla
Feb 12, 1988·Science·K G FieldR A Raff
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J H GundersonM L Sogin
Aug 1, 1974·Lipids·L J GoadT W Goodwin
Aug 1, 1974·Lipids·W R Nes
Jul 16, 1973·European Journal of Biochemistry·M Rohmer, R D Brandt
May 1, 1966·The Journal of protozoology·B L WilliamsJ F Ryley
Aug 1, 1966·The Journal of protozoology·S HalevyH Katan
Mar 1, 1967·Scientific American·E F Adolph
Feb 1, 1984·Molecular and Biochemical Parasitology·L J GoadD H Beach
Feb 1, 1980·The Journal of protozoology·N D LevineF G Wallace
Dec 18, 2001·The Journal of Urology·Arnaud MejeanBertrand Dufour
Dec 1, 1960·Archives of Biochemistry and Biophysics·E HEFTMANNG U LIDDEL
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W D Nes, A E Stafford

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Citations

Sep 5, 2008·Lipids·Galina I LepeshevaMichael R Waterman
Jan 31, 2004·Phytochemistry·Ran XuSeiichi P T Matsuda
Aug 30, 2003·Phytochemistry·W David Nes
Sep 12, 2001·Molecular and Biochemical Parasitology·B M JoubertF S Buckner
Jun 19, 2001·Organic Letters·B M JoubertS P Matsuda
Apr 30, 2010·BMC Research Notes·Valentina Mercanti, Pierre Cosson
Nov 2, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoji Tachibana
Sep 11, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Haruhisa Kikuchi
Jan 1, 2002·The Arabidopsis Book·Pierre Benveniste
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·A BellamineM R Waterman
Mar 7, 2014·Environmental Microbiology Reports·Laura VillanuevaJaap S Sinninghe Damsté
Sep 17, 2013·Eukaryotic Cell·Xiaoli DuMarkus Maniak
Jun 28, 2003·Natural Product Reports·Michael J R SeguraSeiichi P T Matsuda
Mar 15, 2006·The Plant Cell·Tomomi MorikawaDaisaku Ohta
Nov 1, 1994·Antimicrobial Agents and Chemotherapy·S T FurlongJ A Fishman
Jul 3, 2021·Marine Drugs·Valery M DembitskyVladimir V Poroikov
Sep 10, 2011·Chemical Reviews·W David Nes

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