Stevens-johnson syndrome induced by vandetanib.

Annals of Dermatology
Jimi YoonChi Yeon Kim

Abstract

Vandetanib is a once-daily oral anticancer drug that selectively inhibits key signaling pathways in cancer by targeting vascular endothelial growth factor receptors, epidermal growth factor receptors tyrosine kinase, and rearranged during transfection-dependent tumor cell proliferation and survival. The most frequently reported adverse events attributed to vandetanib include diarrhea, elevated aminotransferase, asymptomatic corrected QT interval prolongation, and hypertension. Though a number of randomized, doubleblind studies, including cutaneous adverse events attributed to vandetanib, have been reported along with these general symptoms, no case of Stevens-Johnson syndrome (SJS) has been reported. This paper demonstrates a case of SJS induced by vandetanib.

References

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Citations

Nov 20, 2013·Advances in Therapy·Enrique GrandeJaume Capdevila
Jun 23, 2012·Clinical Medicine Insights. Oncology·Nils DegrauweHari A Deshpande
Sep 16, 2014·Journal of the American Academy of Dermatology·Dolores Caro-GutiérrezJosé Luis López Estebaranz
Jun 21, 2014·The American Journal of Medicine·Barry Ladizinski, Christopher Sankey
Oct 19, 2016·Expert Review of Anticancer Therapy·Poupak FallahiAlessandro Antonelli
Sep 18, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Steven MaximusVictor C Joe
Aug 2, 2018·Annals of Dermatology·Ji Hong LimHei Sung Kim
Jul 30, 2020·Cutaneous and Ocular Toxicology·Baran AkagunduzHalis Suleyman
Oct 9, 2021·Journal of Cutaneous Pathology·Riyad N H SeervaiJonathan L Curry

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Methods Mentioned

BETA
biopsy

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