Stevens-Johnson syndrome, respiratory distress and acute renal failure due to synergic bleomycin-cisplatin toxicity.

Journal of Clinical Pharmacology
A BrodskyD Goldenberg

Abstract

A patient presenting with a cervix uteri epidermoid carcinoma had acute renal failure after treatment with cisplatin and bleomycin. She later developed fatal bleomycin-induced pneumonitis and Stevens-Johnson syndrome. This is a very rare association of adverse effects. The risk of causing a drug interaction thus increasing the severity of bleomycin undesired effects must be taken into account when a nephrotoxic drug is added to the former. The authors stress the importance of monitoring renal function under these conditions.

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Citations

Nov 21, 2007·Dermatologic Clinics·Rachel E Sanborn, David A Sauer
Jan 28, 2005·The Journal of Dermatology·Yoshihiro UmebayashiMichio Ogasawara
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Oct 11, 2013·Anti-cancer Drugs·Alyx C RosenMario E Lacouture
Mar 10, 2019·Apoptosis : an International Journal on Programmed Cell Death·Jintaek Im, Richard Seonghun Nho

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